| Interaction of the p85 subunit of PI 3‐kinase and its N‐terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. G Panayotou, B Bax, I Gout, M Federwisch, B Wroblowski, R Dhand, ... The EMBO journal 11 (12), 4261-4272, 1992 | 148 | 1992 |
| Structure‐function analysis of human interleukin‐6: Evidence for the involvement of the carboxy‐terminus in function A Krüttgen, S Rose-John, C Möller, B Wroblowski, A Wollmer, J Müllberg, ... FEBS letters 262 (2), 323-326, 1990 | 97 | 1990 |
| Molecular mechanisms of pressure induced conformational changes in BPTI B Wroblowski, JF Díaz, K Heremans, Y Engelborghs Proteins: Structure, Function, and Bioinformatics 25 (4), 446-455, 1996 | 92 | 1996 |
| 5-Substituted pyrimidines with a 1, 5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral … T Ostrowski, B Wroblowski, R Busson, J Rozenski, E De Clercq, ... Journal of medicinal chemistry 41 (22), 4343-4353, 1998 | 84 | 1998 |
| Calculation of pathways for the conformational transition between the GTP‐ and GDP‐bound states of the Ha‐ras‐p21 protein: Calculations with explicit solvent … J Fernando Díaz, B Wroblowski, J Schlitter, Y Engelborghs Proteins: Structure, Function, and Bioinformatics 28 (3), 434-451, 1997 | 81 | 1997 |
| Small molecule binding to Alzheimer risk factor CD33 promotes Aβ phagocytosis LA Miles, SJ Hermans, GAN Crespi, JH Gooi, L Doughty, TL Nero, ... Iscience 19, 110-118, 2019 | 63 | 2019 |
| Extending kinome coverage by analysis of kinase inhibitor broad profiling data E Jacoby, G Tresadern, S Bembenek, B Wroblowski, C Buyck, JM Neefs, ... Drug Discovery Today 20 (6), 652-658, 2015 | 54 | 2015 |
| Modelling pathways of alpha-chymotrypsin activation and deactivation. B Wroblowski, JF Diaz, J Schlitter, Y Engelborghs Protein engineering 10 (10), 1163-1174, 1997 | 49 | 1997 |
| Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition JF Diaz, B Wroblowski, Y Engelborghs Biochemistry 34 (37), 12038-12047, 1995 | 49 | 1995 |
| Pyrazolyl quinoxaline kinase inhibitors G Saxty, CW Murray, V Berdini, GE Besong, CCF Hamlett, CN Johnson, ... US Patent 8,895,601, 2014 | 34 | 2014 |
| Oligonucleotides Composed of 2‘-Deoxy-1‘,5‘-anhydro-d-mannitol Nucleosides with a Purine Base Moiety N Hossain, B Wroblowski, A Van Aerschot, J Rozenski, A De Bruyn, ... The Journal of Organic Chemistry 63 (5), 1574-1582, 1998 | 31 | 1998 |
| Oligonucleotide Analogues with 4‐Hydroxy‐N‐Acetylprolinol as Sugar Substitute G Ceulemans, A Van Aerschot, B Wroblowski, J Rozenski, C Hendrix, ... Chemistry–A European Journal 3 (12), 1997-2010, 1997 | 31 | 1997 |
| Some 6-aza-5-substituted-2′-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase I Basnak, M Sun, TA Hamor, F Focher, A Verri, S Spadari, B Wroblowski, ... Nucleosides & nucleotides 17 (1-3), 187-206, 1998 | 29 | 1998 |
| Pyrazolyl quinoxaline kinase inhibitors G Saxty, CW Murray, V Berdini, GE Besong, CCF Hamlett, CN Johnson, ... US Patent 9,464,071, 2016 | 26 | 2016 |
| Molecular‐Dynamics Studies of Single‐Stranded Hexitol, Altritol, Mannitol, and Ribose Nucleic Acids (HNA, MNA, ANA, and RNA, Resp.) and of the Stability of HNA⋅ RNA, ANA⋅ RNA … M Froeyen, B Wroblowski, R Esnouf, H De Winter, B Allart, E Lescrinier, ... Helvetica Chimica Acta 83 (9), 2153-2182, 2000 | 21 | 2000 |
| Pyrazolyl quinoxaline kinase inhibitors G Saxty, CW Murray, V Berdini, GE Besong, CCF Hamlett, CN Johnson, ... US Patent 9,850,228, 2017 | 20 | 2017 |
| Prediction of protein kinase–ligand interactions through 2.5 D kinochemometrics N Bosc, B Wroblowski, C Meyer, P Bonnet Journal of chemical information and modeling 57 (1), 93-101, 2017 | 18 | 2017 |
| The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor B Wroblowski, MJ Wigglesworth, PG Szekeres, GD Smith, SS Rahman, ... Journal of medicinal chemistry 52 (3), 818-825, 2009 | 18 | 2009 |
| A proteometric analysis of human kinome: insight into discriminant conformation-dependent residues N Bosc, B Wroblowski, S Aci-Sèche, C Meyer, P Bonnet ACS Chemical Biology 10 (12), 2827-2840, 2015 | 15 | 2015 |
| Exploring protein kinase conformation using swarm-enhanced sampling molecular dynamics A Atzori, NJ Bruce, KK Burusco, B Wroblowski, P Bonnet, RA Bryce Journal of chemical information and modeling 54 (10), 2764-2775, 2014 | 15 | 2014 |
