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Philip Jewsbury
Philip Jewsbury
AstraZeneca Pharmaceuticals
Verified email at wasabi1.plus.com
Title
Cited by
Cited by
Year
A review of protein-small molecule docking methods
RD Taylor, PJ Jewsbury, JW Essex
Journal of computer-aided molecular design 16, 151-166, 2002
10062002
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
TG Davies, J Bentley, CE Arris, FT Boyle, NJ Curtin, JA Endicott, ...
Nature structural biology 9 (10), 745-749, 2002
2782002
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
CE Arris, FT Boyle, AH Calvert, NJ Curtin, JA Endicott, EF Garman, ...
Journal of medicinal chemistry 43 (15), 2797-2804, 2000
2692000
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein …
KM Foote, K Blades, A Cronin, S Fillery, SS Guichard, L Hassall, I Hickson, ...
Journal of medicinal chemistry 56 (5), 2125-2138, 2013
2432013
Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and Rad3 related (ATR) kinase with application as an anticancer agent
KM Foote, JWM Nissink, T McGuire, P Turner, S Guichard, JWT Yates, ...
Journal of medicinal chemistry 61 (22), 9889-9907, 2018
2312018
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
S Ashton, YH Song, J Nolan, E Cadogan, J Murray, R Odedra, J Foster, ...
Science translational medicine 8 (325), 325ra17-325ra17, 2016
2152016
N2-substituted O 6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
IR Hardcastle, CE Arris, J Bentley, FT Boyle, Y Chen, NJ Curtin, ...
Journal of medicinal chemistry 47 (15), 3710-3722, 2004
1532004
Imidazo [1, 2-a] pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation
M Anderson, JF Beattie, GA Breault, J Breed, KF Byth, JD Culshaw, ...
Bioorganic & Medicinal Chemistry Letters 13 (18), 3021-3026, 2003
1502003
Imidazo [1, 2-a] pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation
M Anderson, JF Beattie, GA Breault, J Breed, KF Byth, JD Culshaw, ...
Bioorganic & Medicinal Chemistry Letters 13 (18), 3021-3026, 2003
1502003
FDS: flexible ligand and receptor docking with a continuum solvent model and soft‐core energy function
RD Taylor, PJ Jewsbury, JW Essex
Journal of computational chemistry 24 (13), 1637-1656, 2003
1242003
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4, 6-bis anilino pyrimidines
JF Beattie, GA Breault, RPA Ellston, S Green, PJ Jewsbury, CJ Midgley, ...
Bioorganic & medicinal chemistry letters 13 (18), 2955-2960, 2003
1122003
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O 6-substituted guanine derivatives
AE Gibson, CE Arris, J Bentley, FT Boyle, NJ Curtin, TG Davies, ...
Journal of medicinal chemistry 45 (16), 3381-3393, 2002
1092002
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
KL Sayle, J Bentley, FT Boyle, AH Calvert, Y Cheng, NJ Curtin, ...
Bioorganic & medicinal chemistry letters 13 (18), 3079-3082, 2003
922003
The proximal residue largely determines the CO distortion in carbon monoxy globin proteins. An ab initio study of a heme prosthetic unit
P Jewsbury, S Yamamoto, T Minato, M Saito, T Kitagawa
The Journal of Physical Chemistry 99 (33), 12677-12685, 1995
841995
The proximal residue largely determines the CO distortion in carbon monoxy globin proteins. An ab initio study of a heme prosthetic unit
P Jewsbury, S Yamamoto, T Minato, M Saito, T Kitagawa
The Journal of Physical Chemistry 99 (33), 12677-12685, 1995
841995
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase
JG Cumming, CL McKenzie, SG Bowden, D Campbell, DJ Masters, ...
Bioorganic & medicinal chemistry letters 14 (21), 5389-5394, 2004
752004
4-Alkoxy-2, 6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2
V Mesguiche, RJ Parsons, CE Arris, J Bentley, FT Boyle, NJ Curtin, ...
Bioorganic & medicinal chemistry letters 13 (2), 217-222, 2003
702003
The distal residue-CO interaction in carbonmonoxy myoglobins: a molecular dynamics study of two distal histidine tautomers
P Jewsbury, T Kitagawa
Biophysical journal 67 (6), 2236-2250, 1994
661994
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2, 4-bis anilino pyrimidines
GA Breault, RPA Ellston, S Green, SR James, PJ Jewsbury, CJ Midgley, ...
Bioorganic & medicinal chemistry letters 13 (18), 2961-2966, 2003
642003
Einstein A-coefficients and transition dipole moments for some ion-pair to valence transitions in I2
K Lawley, P Jewsbury, T Ridley, P Langridge-Smith, R Donovan
Molecular Physics 75 (4), 811-828, 1992
641992
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