Erik W Martin
Erik W Martin
Dewpoint Therapeutics
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G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
P Yang, C Mathieu, RM Kolaitis, P Zhang, J Messing, U Yurtsever, Z Yang, ...
Cell 181 (2), 325-345. e28, 2020
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
EW Martin, AS Holehouse, I Peran, M Farag, JJ Incicco, A Bremer, ...
Science 367 (6478), 694-699, 2020
A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing
A Wang, AE Conicella, HB Schmidt, EW Martin, SN Rhoads, AN Reeb, ...
The EMBO journal 37 (5), e97452, 2018
Relationship of sequence and phase separation in protein low-complexity regions
EW Martin, T Mittag
Biochemistry 57 (17), 2478-2487, 2018
Cancer mutations of the tumor suppressor SPOP disrupt the formation of active, phase-separated compartments
JJ Bouchard, JH Otero, DC Scott, E Szulc, EW Martin, N Sabri, D Granata, ...
Molecular cell 72 (1), 19-36. e8, 2018
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
A Bremer, M Farag, WM Borcherds, I Peran, EW Martin, RV Pappu, ...
Nature chemistry 14 (2), 196-207, 2022
Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation
EW Martin, AS Holehouse, CR Grace, A Hughes, RV Pappu, T Mittag
Journal of the American Chemical Society 138 (47), 15323-15335, 2016
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
EW Martin, AS Holehouse
Emerging topics in life sciences 4 (3), 307-329, 2020
Conformational ensembles of an intrinsically disordered protein consistent with NMR, SAXS, and single-molecule FRET
GNW Gomes, M Krzeminski, A Namini, EW Martin, T Mittag, ...
Journal of the American Chemical Society 142 (37), 15697-15710, 2020
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
EW Martin, FE Thomasen, NM Milkovic, MJ Cuneo, CR Grace, A Nourse, ...
Nucleic acids research 49 (5), 2931-2945, 2021
A multi-step nucleation process determines the kinetics of prion-like domain phase separation
EW Martin, TS Harmon, JB Hopkins, S Chakravarthy, JJ Incicco, P Schuck, ...
Nature Communications 12 (1), 4513, 2021
A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer
RM Robertson, J Yao, S Gajewski, G Kumar, EW Martin, CO Rock, ...
Nature structural & molecular biology 24 (8), 666-671, 2017
Modulation of the free energy of the primary quinone acceptor (QA) in reaction centers from Rhodobacter sphaeroides: contributions from the protein and protein–lipid†…
L Rinyu, EW Martin, E Takahashi, P Marůti, CA Wraight
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1655, 93-101, 2004
Protein network structure enables switching between liquid and gel states
JD Schmit, JJ Bouchard, EW Martin, T Mittag
Journal of the American Chemical Society 142 (2), 874-883, 2019
Hydrogen Bonding and Spin Density Distribution in the QB Semiquinone of Bacterial Reaction Centers and Comparison with the QA Site
E Martin, RI Samoilova, KV Narasimhulu, TJ Lin, PJ O’Malley, CA Wraight, ...
Journal of the American Chemical Society 133 (14), 5525-5537, 2011
Integrative analysis suggests cell type–specific decoding of NF-κB dynamics
EW Martin, A Pacholewska, H Patel, H Dashora, MH Sung
Science signaling 13 (620), eaax7195, 2020
Structural biases in disordered proteins are prevalent in the cell
D Moses, K Guadalupe, F Yu, E Flores, AR Perez, R McAnelly, ...
Nature Structural & Molecular Biology 31 (2), 283-292, 2024
Small-angle X-ray scattering experiments of monodisperse intrinsically disordered protein samples close to the solubility limit
EW Martin, JB Hopkins, T Mittag
Methods in enzymology 646, 185-222, 2021
Hydrogen Bonds between Nitrogen Donors and the Semiquinone in the QB Site of Bacterial Reaction Centers
E Martin, RI Samoilova, KV Narasimhulu, CA Wraight, SA Dikanov
Journal of the American Chemical Society 132 (33), 11671-11677, 2010
Hydrogen Bonding between the QB Site Ubisemiquinone and Ser-L223 in the Bacterial Reaction Center: A Combined Spectroscopic and Computational Perspective
E Martin, A Baldansuren, TJ Lin, RI Samoilova, CA Wraight, SA Dikanov, ...
Biochemistry 51 (45), 9086-9093, 2012
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