Следене
J David Lawson
J David Lawson
Mirati Therapeutics
Потвърден имейл адрес: mirati.com
Заглавие
Позовавания
Позовавания
Година
Intrinsically disordered protein
AK Dunker, JD Lawson, CJ Brown, RM Williams, P Romero, JS Oh, ...
Journal of molecular graphics and modelling 19 (1), 26-59, 2001
28252001
Intrinsic disorder and protein function
AK Dunker, CJ Brown, JD Lawson, LM Iakoucheva, Z Obradović
Biochemistry 41 (21), 6573-6582, 2002
21072002
Intrinsic disorder in cell-signaling and cancer-associated proteins
LM Iakoucheva, CJ Brown, JD Lawson, Z Obradović, AK Dunker
Journal of molecular biology 323 (3), 573-584, 2002
14102002
Protein flexibility and intrinsic disorder
P Radivojac, Z Obradovic, DK Smith, G Zhu, S Vucetic, CJ Brown, ...
Protein Science 13 (1), 71-80, 2004
3952004
DisProt: a database of protein disorder
S Vucetic, Z Obradovic, V Vacic, P Radivojac, K Peng, LM Iakoucheva, ...
Bioinformatics 21 (1), 137-140, 2005
2842005
Is myosin a" back door" enzyme?
RG Yount, D Lawson, I Rayment
Biophysical journal 68 (4 Suppl), 44S, 1995
1941995
Fragment-based discovery of a small molecule inhibitor of Bruton’s tyrosine kinase
CR Smith, DR Dougan, M Komandla, T Kanouni, B Knight, JD Lawson, ...
Journal of Medicinal Chemistry 58 (14), 5437-5444, 2015
702015
Molecular dynamics analysis of structural factors influencing back door pi release in myosin
JD Lawson, E Pate, I Rayment, RG Yount
Biophysical journal 86 (6), 3794-3803, 2004
662004
Structural model of the regulatory domain of smooth muscle heavy meromyosin
JL Wahlstrom, MA Randall, JD Lawson, DE Lyons, WF Siems, GJ Crouch, ...
Journal of Biological Chemistry 278 (7), 5123-5131, 2003
412003
A back-to-front fragment-based drug design search strategy targeting the DFG-out pocket of protein tyrosine kinases
H Iwata, H Oki, K Okada, T Takagi, M Tawada, Y Miyazaki, S Imamura, ...
ACS medicinal chemistry letters 3 (4), 342-346, 2012
302012
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors
M Adams, T Kobayashi, JD Lawson, M Saitoh, K Shimokawa, SV Bigi, ...
Bioorganic & medicinal chemistry letters 26 (3), 1086-1089, 2016
252016
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 2
C McBride, Z Cheruvallath, M Komandla, M Tang, P Farrell, JD Lawson, ...
Bioorganic & Medicinal Chemistry Letters 26 (12), 2779-2783, 2016
232016
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1
Z Cheruvallath, M Tang, C McBride, M Komandla, J Miura, T Ton-Nu, ...
Bioorganic & Medicinal Chemistry Letters 26 (12), 2774-2778, 2016
212016
Isolation of chloroform-resistant mutants of filamentous phage: localization in models of phage structure
JS Oh, DR Davies, JD Lawson, GE Arnold, AK Dunker
Journal of molecular biology 287 (3), 449-457, 1999
201999
Discovery of Potent, Selective, and Brain-Penetrant 1H-Pyrazol-5-yl-1H-pyrrolo[2,3-b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors
M Fushimi, I Fujimori, T Wakabayashi, T Hasui, Y Kawakita, K Imamura, ...
Journal of Medicinal Chemistry 62 (10), 4915-4935, 2019
152019
Design, synthesis and optimization of 7-substituted-pyrazolo [4, 3-b] pyridine ALK5 (activin receptor-like kinase 5) inhibitors
M Sabat, H Wang, N Scorah, JD Lawson, J Atienza, R Kamran, MS Hixon, ...
Bioorganic & Medicinal Chemistry Letters 27 (9), 1955-1961, 2017
152017
Identification of AHCY inhibitors using novel high-throughput mass spectrometry
N Uchiyama, DR Dougan, JD Lawson, H Kimura, S Matsumoto, Y Tanaka, ...
Biochemical and Biophysical Research Communications 491 (1), 1-7, 2017
142017
MET tyrosine kinase inhibition enhances the antitumor efficacy of an HGF antibody
PJ Farrell, J Matuszkiewicz, D Balakrishna, S Pandya, MS Hixon, ...
Molecular cancer therapeutics 16 (7), 1269-1278, 2017
132017
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
W Keung, A Boloor, J Brown, A Kiryanov, A Gangloff, JD Lawson, ...
Bioorganic & Medicinal Chemistry Letters 27 (4), 1099-1104, 2017
112017
Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors
H Wang, JD Lawson, N Scorah, R Kamran, MS Hixon, J Atienza, ...
Bioorganic & medicinal chemistry letters 26 (17), 4334-4339, 2016
92016
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