Alex S. Holehouse
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A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins
J Wang, JM Choi, AS Holehouse, HO Lee, X Zhang, M Jahnel, ...
Cell 174 (3), 688-699. e16, 2018
Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein
CW Pak, M Kosno, AS Holehouse, SB Padrick, A Mittal, R Ali, AA Yunus, ...
Molecular Cell 63 (1), 72-85, 2016
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
EW Martin*, AS Holehouse*, I Peran*, M Farag, JJ Incicco, A Bremer, ...
Science 367 (6478), 694-699, 2020
Phase separation of a yeast prion protein promotes cellular fitness
TM Franzmann, M Jahnel, A Pozniakovsky, J Mahamid, AS Holehouse, ...
Science 359 (6371), eaao5654, 2018
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
J Guillén-Boixet*, A Kopach*, AS Holehouse, S Wittmann, M Jahnel, ...
Cell 181 (2), 346-361. e17, 2020
Physical principles underlying the complex biology of intracellular phase transitions
JM Choi-✝, AS Holehouse-✝, RV Pappu-✝
Annual Review of Biophysics 49, 107-133, 2020
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
TS Harmon, AS Holehouse, MK Rosen, RV Pappu
elife 6, e30294, 2017
Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles
MT Wei*, S Elbaum-Garfinkle*, AS Holehouse*, CCH Chen, M Feric, ...
Nature Chemistry 9, 1118–1125, 2017
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
J Cubuk, JJ Alston, J Jeremías Incicco, S Singh, MD Stuchell-Brereton, ...
Nature Communications 12 (1), 1–17, 2021
CIDER: resources to analyze sequence-ensemble relationships of intrinsically disordered proteins
AS Holehouse, RK Das, JN Ahad, MOG Richardson, RV Pappu
Biophysical journal 112 (1), 16-21, 2017
Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties
S Boeynaems, AS Holehouse, V Weinhardt, D Kovacs, J Van Lindt, ...
Proceedings of the National Academy of Sciences 116 (16), 7889-7898, 2019
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution
J Fei, M Jadaliha, TS Harmon, ITS Li, B Hua, Q Hao, AS Holehouse, ...
Journal of cell science 130 (24), 4180-4192, 2017
Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation
EW Martin*, AS Holehouse*, CR Grace, A Hughes, RV Pappu, T Mittag
Journal of the American Chemical Society 138 (47), 15323-15335, 2016
Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana
SK Powers, AS Holehouse, DA Korasick, KH Schreiber, NM Clark, H Jing, ...
Molecular cell 76 (1), 177-190. e5, 2019
Functional implications of intracellular phase transitions
AS Holehouse, RV Pappu
Biochemistry 57 (17), 2415-2423, 2018
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
DW Sanders, CC Jumper, PJ Ackerman, D Bracha, A Donlic, H Kim, ...
Elife 10, e65962, 2021
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
EW Martin, AS Holehouse
Emerging topics in life sciences 4 (3), 307-329, 2020
Phase Separation of Intrinsically Disordered Proteins
AE Posey*, AS Holehouse*, RV Pappu
Methods in Enzymology, 2018
Arginine-enriched mixed-charge domains provide cohesion for nuclear speckle condensation
JA Greig, TA Nguyen, M Lee, AS Holehouse, AE Posey, RV Pappu, ...
Molecular cell 77 (6), 1237-1250. e4, 2020
A high-throughput mutational scan of an intrinsically disordered acidic transcriptional activation domain
MV Staller, AS Holehouse, D Swain-Lenz, RK Das, RV Pappu, BA Cohen
Cell Systems 6 (4), 444-455. e6, 2018
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