Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells J Krönke, ND Udeshi, A Narla, P Grauman, SN Hurst, M McConkey, ... Science 343 (6168), 301-305, 2014 | 1426 | 2014 |
Selective killing of cancer cells by a small molecule targeting the stress response to ROS L Raj, T Ide, AU Gurkar, M Foley, M Schenone, X Li, NJ Tolliday, ... Nature 475 (7355), 231-234, 2011 | 1116 | 2011 |
Target identification and mechanism of action in chemical biology and drug discovery M Schenone, V Dančík, BK Wagner, PA Clemons Nature chemical biology 9 (4), 232-240, 2013 | 966 | 2013 |
Identifying the proteins to which small-molecule probes and drugs bind in cells SE Ong, M Schenone, AA Margolin, X Li, K Do, MK Doud, DR Mani, ... Proceedings of the National Academy of Sciences 106 (12), 4617-4622, 2009 | 355 | 2009 |
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability M Munschauer, CT Nguyen, K Sirokman, CR Hartigan, L Hogstrom, ... Nature 561 (7721), 132-136, 2018 | 270 | 2018 |
The blood coagulation cascade M Schenone, BC Furie, B Furie Current opinion in hematology 11 (4), 272-277, 2004 | 222 | 2004 |
WRN helicase is a synthetic lethal target in microsatellite unstable cancers EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ... Nature 568 (7753), 551-556, 2019 | 219 | 2019 |
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9 RK Schneider, M Schenone, MV Ferreira, R Kramann, CE Joyce, ... Nature medicine 22 (3), 288-297, 2016 | 200 | 2016 |
Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms V Rusu, E Hoch, JM Mercader, DE Tenen, M Gymrek, CR Hartigan, ... Cell 170 (1), 199-212. e20, 2017 | 142 | 2017 |
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL Q Wen, B Goldenson, SJ Silver, M Schenone, V Dancik, Z Huang, ... Cell 150 (3), 575-589, 2012 | 142 | 2012 |
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6 W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ... ACS Chemical Biology 13 (11), 3131-3141, 2018 | 110 | 2018 |
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions V Mohanan, T Nakata, AN Desch, C Lévesque, A Boroughs, G Guzman, ... Science 359 (6380), 1161-1166, 2018 | 91 | 2018 |
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics L De Waal, TA Lewis, MG Rees, A Tsherniak, X Wu, PS Choi, L Gechijian, ... Nature chemical biology 12 (2), 102-108, 2016 | 78 | 2016 |
Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis GJ Sandoval, JL Pulice, H Pakula, M Schenone, DY Takeda, M Pop, ... Molecular cell 71 (4), 554-566. e7, 2018 | 74 | 2018 |
Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein JL Rios-Steiner, M Schenone, I Mochalkin, A Tulinsky, FJ Castellino Journal of molecular biology 308 (4), 705-719, 2001 | 72 | 2001 |
The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer M Gandhi, M Groß, JM Holler, SAA Coggins, N Patil, JH Leupold, ... Nature communications 11 (1), 3214, 2020 | 67 | 2020 |
Domain interactions between streptokinase and human plasminogen JA Loy, X Lin, M Schenone, FJ Castellino, XC Zhang, J Tang Biochemistry 40 (48), 14686-14695, 2001 | 66 | 2001 |
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation A Basak, M Munschauer, CA Lareau, KE Montbleau, JC Ulirsch, ... Nature genetics 52 (2), 138-145, 2020 | 65 | 2020 |
Empirical Bayes analysis of quantitative proteomics experiments AA Margolin, SE Ong, M Schenone, R Gould, SL Schreiber, SA Carr, ... PloS one 4 (10), e7454, 2009 | 55 | 2009 |
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer SR Viswanathan, MF Nogueira, CG Buss, JM Krill-Burger, MJ Wawer, ... Nature genetics 50 (7), 937-943, 2018 | 48 | 2018 |