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Philip C. Biggin
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Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes
E Gazit, IR Miller, PC Biggin, MSP Sansom, Y Shai
Journal of molecular biology 258 (5), 860-870, 1996
3351996
A hydrophobic gating mechanism for nanopores
O Beckstein, PC Biggin, MSP Sansom
The Journal of Physical Chemistry B 105 (51), 12902-12905, 2001
3112001
Accurate calculation of the absolute free energy of binding for drug molecules
M Aldeghi, A Heifetz, MJ Bodkin, S Knapp, PC Biggin
Chemical science 7 (1), 207-218, 2016
2452016
Simulation approaches to ion channel structure-function relationships.
DP Tieleman, PC Biggin, GR Smith, MS Sansom
Quaterley Reviews in Biophysics 34 (4), 473-561, 2001
2422001
Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides
SD Buckingham, PC Biggin, BM Sattelle, LA Brown, DB Sattelle
Molecular pharmacology 68 (4), 942-951, 2005
2332005
Potassium channels: structures, models, simulations
MSP Sansom, IH Shrivastava, JN Bright, J Tate, CE Capener, PC Biggin
Biochimica et Biophysica Acta (BBA)-Biomembranes 1565 (2), 294-307, 2002
2162002
The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy
P Luik, C Chew, J Aittoniemi, J Chang, P Wentworth Jr, RA Dwek, ...
Proceedings of the National Academy of Sciences 106 (31), 12712-12716, 2009
2042009
Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster
DB Sattelle, AK Jones, BM Sattelle, K Matsuda, R Reenan, PC Biggin
Bioessays 27 (4), 366-376, 2005
1862005
Rapid and accurate prediction and scoring of water molecules in protein binding sites
GA Ross, GM Morris, PC Biggin
PloS one 7 (3), e32036, 2012
1802012
Water at the nanoscale
MSP Sansom, PC Biggin
Nature 414 (6860), 157-159, 2001
1792001
K+ versus Na+ ions in a K channel selectivity filter: a simulation study
IH Shrivastava, DP Tieleman, PC Biggin, MSP Sansom
Biophysical journal 83 (2), 633-645, 2002
1772002
Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump
J Marcoux, SC Wang, A Politis, E Reading, J Ma, PC Biggin, M Zhou, ...
Proceedings of the National Academy of Sciences 110 (24), 9704-9709, 2013
1672013
Simulation studies of the interaction of antimicrobial peptides and lipid bilayers
P La Rocca, PC Biggin, DP Tieleman, MSP Sansom
Biochimica et Biophysica Acta (BBA)-Biomembranes 1462 (1-2), 185-200, 1999
1601999
Interactions of α-helices with lipid bilayers: a review of simulation studies
PC Biggin, MSP Sansom
Biophysical chemistry 76 (3), 161-183, 1999
1521999
Ion channel gating: insights via molecular simulations
O Beckstein, PC Biggin, P Bond, JN Bright, C Domene, A Grottesi, ...
FEBS letters 555 (1), 85-90, 2003
1472003
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
D Laverty, P Thomas, M Field, OJ Andersen, MG Gold, PC Biggin, ...
Nature structural & molecular biology 24 (11), 977-985, 2017
1442017
Towards understanding promiscuity in multidrug efflux pumps
K Wong, J Ma, A Rothnie, PC Biggin, ID Kerr
Trends in biochemical sciences 39 (1), 8-16, 2014
1392014
Predictive low-glucose insulin suspension reduces duration of nocturnal hypoglycemia in children without increasing ketosis
BA Buckingham, D Raghinaru, F Cameron, BW Bequette, HP Chase, ...
Diabetes Care 38 (7), 1197-1204, 2015
1382015
Additional acetylcholine (ACh) binding site at α4/α4 interface of (α4β2) 2α4 nicotinic receptor influences agonist sensitivity
S Mazzaferro, N Benallegue, A Carbone, F Gasparri, R Vijayan, ...
Journal of Biological Chemistry 286 (35), 31043-31054, 2011
135*2011
Predictions of ligand selectivity from absolute binding free energy calculations
M Aldeghi, A Heifetz, MJ Bodkin, S Knapp, PC Biggin
Journal of the American Chemical Society 139 (2), 946-957, 2017
1192017
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Articles 1–20