| Global chemical effects of the microbiome include new bile-acid conjugations RA Quinn, AV Melnik, A Vrbanac, T Fu, KA Patras, MP Christy, Z Bodai, ... Nature 579 (7797), 123-129, 2020 | 370 | 2020 |
| A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics MG Charest, CD Lerner, JD Brubaker, DR Siegel, AG Myers Science 308 (5720), 395-398, 2005 | 350 | 2005 |
| Facile, novel methodology for the synthesis of spiro [pyrrolidin‐3, 3′‐oxindoles]: catalyzed ring expansion reactions of cyclopropanes by aldimines PB Alper, C Meyers, A Lerchner, DR Siegel, EM Carreira Angewandte Chemie International Edition 38 (21), 3186-3189, 1999 | 309 | 1999 |
| Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics AN Cowell, ES Istvan, AK Lukens, MG Gomez-Lorenzo, M Vanaerschot, ... Science 359 (6372), 191-199, 2018 | 217 | 2018 |
| Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin A Vidal-Gadea, S Topper, L Young, A Crisp, L Kressin, E Elbel, T Maples, ... Proceedings of the National Academy of Sciences 108 (42), 17504-17509, 2011 | 197 | 2011 |
| Metal-free oxidation of aromatic carbon–hydrogen bonds through a reverse-rebound mechanism C Yuan, Y Liang, T Hernandez, A Berriochoa, KN Houk, D Siegel Nature 499 (7457), 192-196, 2013 | 190 | 2013 |
| Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion C Yuan, CT Chang, A Axelrod, D Siegel Journal of the American Chemical Society 132 (17), 5924-5925, 2010 | 178 | 2010 |
| Palmitic acid hydroxystearic acids activate GPR40, which is involved in their beneficial effects on glucose homeostasis I Syed, J Lee, PM Moraes-Vieira, CJ Donaldson, A Sontheimer, P Aryal, ... Cell metabolism 27 (2), 419-427. e4, 2018 | 158 | 2018 |
| Synthesis of (−)-tetracycline MG Charest, DR Siegel, AG Myers Journal of the American Chemical Society 127 (23), 8292-8293, 2005 | 152 | 2005 |
| Total synthesis of garsubellin A DR Siegel, SJ Danishefsky Journal of the American Chemical Society 128 (4), 1048-1049, 2006 | 143 | 2006 |
| A robust platform for the synthesis of new tetracycline antibiotics C Sun, Q Wang, JD Brubaker, PM Wright, CD Lerner, K Noson, M Charest, ... Journal of the American Chemical Society 130 (52), 17913-17927, 2008 | 140 | 2008 |
| Open-source discovery of chemical leads for next-generation chemoprotective antimalarials Y Antonova-Koch, S Meister, M Abraham, MR Luth, S Ottilie, AK Lukens, ... Science 362 (6419), eaat9446, 2018 | 110 | 2018 |
| Differentiation of nonconventional “carbanions”—the total synthesis of nemorosone and clusianone C Tsukano, DR Siegel, SJ Danishefsky Angewandte Chemie International Edition 46 (46), 8840-8844, 2007 | 110 | 2007 |
| Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks SK Piasecki, CA Taylor, JF Detelich, J Liu, J Zheng, A Komsoukaniants, ... Chemistry & biology 18 (10), 1331-1340, 2011 | 97 | 2011 |
| Synthesis of a broad array of highly functionalized, enantiomerically pure cyclohexanecarboxylic acid derivatives by microbial dihydroxylation of benzoic acid and subsequent … AG Myers, DR Siegel, DJ Buzard, MG Charest Organic Letters 3 (18), 2923-2926, 2001 | 97 | 2001 |
| Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals MJ Kolar, S Konduri, T Chang, H Wang, C McNerlin, L Ohlsson, M Härröd, ... Journal of Biological Chemistry 294 (27), 10698-10707, 2019 | 88 | 2019 |
| PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms P Zhou, A Santoro, OD Peroni, AT Nelson, A Saghatelian, D Siegel, ... The Journal of clinical investigation 129 (10), 4138-4150, 2019 | 77 | 2019 |
| Semaphorin3a promotes advanced diabetic nephropathy PK Aggarwal, D Veron, DB Thomas, D Siegel, G Moeckel, M Kashgarian, ... Diabetes 64 (5), 1743-1759, 2015 | 74 | 2015 |
| ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids R Patel, A Santoro, P Hofer, D Tan, M Oberer, AT Nelson, S Konduri, ... Nature 606 (7916), 968-975, 2022 | 70 | 2022 |
| Recent developments in polyene cyclizations and their applications in natural product synthesis AGM Barrett, TK Ma, T Mies Synthesis 51 (01), 67-82, 2019 | 68 | 2019 |
