| Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain L Zhao, D Cao, T Chen, Y Wang, Z Miao, Y Xu, W Chen, X Wang, Y Li, ... Journal of medicinal chemistry 56 (10), 3833-3851, 2013 | 145 | 2013 |
| Structure of the mammalian TRPM7, a magnesium channel required during embryonic development J Duan, Z Li, J Li, RE Hulse, A Santa-Cruz, WC Valinsky, SA Abiria, ... Proceedings of the National Academy of Sciences 115 (35), E8201-E8210, 2018 | 122 | 2018 |
| Structure of the mouse TRPC4 ion channel J Duan, J Li, B Zeng, GL Chen, X Peng, Y Zhang, J Wang, DE Clapham, ... Nature communications 9 (1), 3102, 2018 | 114 | 2018 |
| Structure of full-length human TRPM4 J Duan, Z Li, J Li, A Santa-Cruz, S Sanchez-Martinez, J Zhang, ... Proceedings of the National Academy of Sciences 115 (10), 2377-2382, 2018 | 91 | 2018 |
| Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function J Duan, J Li, GL Chen, Y Ge, J Liu, K Xie, X Peng, W Zhou, J Zhong, ... Science advances 5 (7), eaaw7935, 2019 | 82 | 2019 |
| Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90 J Li, L Sun, C Xu, F Yu, H Zhou, Y Zhao, J Zhang, J Cai, C Mao, L Tang, ... Acta Biochim Biophys Sin 44 (4), 300-306, 2012 | 80 | 2012 |
| Discovery of a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor by virtual screening R Ferreira de Freitas, MS Eram, D Smil, MM Szewczyk, S Kennedy, ... Journal of medicinal chemistry 59 (14), 6838-6847, 2016 | 48 | 2016 |
| Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode J Li, X Zhou, Y Zhang, F Zhong, C Lin, PJ McCormick, F Jiang, J Luo, ... Science bulletin 66 (7), 661, 2021 | 47 | 2021 |
| Discovery of potent N-(isoxazol-5-yl) amides as HSP90 inhibitors D Chen, A Shen, J Li, F Shi, W Chen, J Ren, H Liu, Y Xu, X Wang, X Yang, ... European journal of medicinal chemistry 87, 765-781, 2014 | 46 | 2014 |
| Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332 J Li, PJ McCormick, R Fu, Y Fu, H Jiang, J Zhang | 42 | 2022 |
| The structure of TRPC ion channels J Li, X Zhang, X Song, R Liu, J Zhang, Z Li Cell Calcium 80, 25-28, 2019 | 36 | 2019 |
| Structure-based discovery and development of a series of potent and selective bromodomain and extra-terminal protein inhibitors J Hu, CQ Tian, MS Damaneh, Y Li, D Cao, K Lv, T Yu, T Meng, D Chen, ... Journal of Medicinal Chemistry 62 (18), 8642-8663, 2019 | 34 | 2019 |
| Structure-based discovery and structural basis of a novel broad-spectrum natural product against the main protease of coronavirus Y Zhang, H Gao, X Hu, Q Wang, F Zhong, X Zhou, C Lin, Y Yang, J Wei, ... Journal of Virology 96 (1), e01253-21, 2022 | 33 | 2022 |
| Discovery of pyrazole as C-terminus of selective BACE1 inhibitors Y Zou, L Xu, W Chen, Y Zhu, T Chen, Y Fu, L Li, L Ma, B Xiong, X Wang, ... European Journal of Medicinal Chemistry 68, 270-283, 2013 | 32 | 2013 |
| Multi-substituted 8-aminoimidazo [1, 2-a] pyrazines by Groebke–Blackburn–Bienaymé reaction and their Hsp90 inhibitory activity J Ren, M Yang, H Liu, D Cao, D Chen, J Li, L Tang, J He, YL Chen, ... Organic & Biomolecular Chemistry 13 (5), 1531-1535, 2015 | 29 | 2015 |
| Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization J Ren, J Li, Y Wang, W Chen, A Shen, H Liu, D Chen, D Cao, Y Li, ... Bioorganic & Medicinal Chemistry Letters 24 (11), 2525-2529, 2014 | 27 | 2014 |
| Fragment-based Drug Discovery of Triazole Inhibitors to Block PDEδ-RAS Protein-protein Interaction BX Danqi Chen, Yuehong Chen, Fulin Lian, Liu Chen, Yanlian Li,Danyan Cao ... European Journal of Medicinal Chemistry, 2018 | 24* | 2018 |
| Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality YZ Guo, LH Sun, D Oberthuer, CY Zhang, JY Shi, JL Di, BL Zhang, ... Scientific Reports 4 (1), 7308, 2014 | 22 | 2014 |
| Structure of SARS-CoV-2 main protease in the apo state X Zhou, F Zhong, C Lin, X Hu, Y Zhang, B Xiong, X Yin, J Fu, W He, ... Science China Life Sciences 64, 656-659, 2021 | 21 | 2021 |
| Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups J Hu, Y Wang, Y Li, D Cao, L Xu, SS Song, MS Damaneh, J Li, Y Chen, ... European Journal of Medicinal Chemistry 150, 156-175, 2018 | 21 | 2018 |
Li-Hua SunShanghai Institute of Applied Physics, Chinese Academy of SciencesПотвърден имейл адрес: sinap.ac.cn
