|Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide|
JP Lévesque, J Hendy, Y Takamatsu, PJ Simmons, LJ Bendall
The Journal of clinical investigation 111 (2), 187-196, 2003
|Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs|
IG Winkler, NA Sims, AR Pettit, V Barbier, B Nowlan, F Helwani, IJ Poulton, ...
Blood, The Journal of the American Society of Hematology 116 (23), 4815-4828, 2010
|Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony …|
JP Lévesque, Y Takamatsu, SK Nilsson, DN Haylock, PJ Simmons
Blood, The Journal of the American Society of Hematology 98 (5), 1289-1297, 2001
|G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow|
CL Semerad, MJ Christopher, F Liu, B Short, PJ Simmons, I Winkler, ...
Blood 106 (9), 3020-3027, 2005
|Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance|
IG Winkler, V Barbier, B Nowlan, RN Jacobsen, CE Forristal, JT Patton, ...
Nature medicine 18 (11), 1651-1657, 2012
|Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins.|
JP Levesque, DI Leavesley, S Niutta, M Vadas, PJ Simmons
The Journal of experimental medicine 181 (5), 1805-1815, 1995
|Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment|
JP Lévesque, J Hendy, Y Takamatsu, B Williams, IG Winkler, PJ Simmons
Experimental hematology 30 (5), 440-449, 2002
|Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.|
J Hatzfeld, ML Li, EL Brown, H Sookdeo, JP Levesque, T O'Toole, ...
The Journal of experimental medicine 174 (4), 925-929, 1991
|Characterization of hematopoietic progenitor mobilization in protease-deficient mice|
JP Levesque, F Liu, PJ Simmons, T Betsuyaku, RM Senior, C Pham, ...
Blood 104 (1), 65-72, 2004
|The endosteal ‘osteoblastic’niche and its role in hematopoietic stem cell homing and mobilization|
JP Lévesque, FM Helwani, IG Winkler
Leukemia 24 (12), 1979-1992, 2010
|Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta|
G Brooke, H Tong, JP Levesque, K Atkinson
Stem cells and development 17 (5), 929-940, 2008
|Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches|
IG Winkler, V Barbier, R Wadley, ACW Zannettino, S Williams, ...
Blood, The Journal of the American Society of Hematology 116 (3), 375-385, 2010
|Release from quiescence of CD34+ CD38-human umbilical cord blood cells reveals their potentiality to engraft adults.|
AA Cardoso, ML Li, P Batard, A Hatzfeld, EL Brown, JP Levesque, ...
Proceedings of the National Academy of Sciences 90 (18), 8707-8711, 1993
|How I treat patients who mobilize hematopoietic stem cells poorly|
LB To, JP Levesque, KE Herbert
Blood, The Journal of the American Society of Hematology 118 (17), 4530-4540, 2011
|Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells|
JP Lévesque, J Hendy, IG Winkler, Y Takamatsu, PJ Simmons
Experimental hematology 31 (2), 109-117, 2003
|Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors|
JP Levesque, DN Haylock, PJ Simmons
|Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor …|
Y Takamatsu, PJ Simmons, RJ Moore, HA Morris, LB To, JP Lévesque
Blood, The Journal of the American Society of Hematology 92 (9), 3465-3473, 1998
|Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1α and vascular endothelial growth factor A in bone marrow|
JP LEvesque, IG Winkler, J Hendy, B Williams, F Helwani, V Barbier, ...
Stem cells 25 (8), 1954-1965, 2007
|Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation|
IG Winkler, AR Pettit, LJ Raggatt, RN Jacobsen, CE Forristal, V Barbier, ...
Leukemia 26 (7), 1594-1601, 2012
|Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone|
IG Winkler, JP Levesque
Experimental hematology 34 (8), 996-1009, 2006