| Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders EJ Baxter, LM Scott, PJ Campbell, C East, N Fourouclas, S Swanton, ... The Lancet 365 (9464), 1054-1061, 2005 | 4400 | 2005 |
| Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study PJ Campbell, LM Scott, G Buck, K Wheatley, CL East, JT Marsden, A Duffy, ... The Lancet 366 (9501), 1945-1953, 2005 | 871 | 2005 |
| Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control I Barbieri, K Tzelepis, L Pandolfini, J Shi, G Millán-Zambrano, SC Robson, ... Nature 552 (7683), 126-131, 2017 | 752 | 2017 |
| Prediction of acute myeloid leukaemia risk in healthy individuals S Abelson, G Collord, SWK Ng, O Weissbrod, N Mendelson Cohen, ... Nature 559 (7714), 400-404, 2018 | 649 | 2018 |
| Effect of mutation order on myeloproliferative neoplasms CA Ortmann, DG Kent, J Nangalia, Y Silber, DC Wedge, J Grinfeld, ... New England Journal of Medicine 372 (7), 601-612, 2015 | 540 | 2015 |
| A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ... Cell reports 17 (4), 1193-1205, 2016 | 525 | 2016 |
| Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis T McKerrell, N Park, T Moreno, CS Grove, H Ponstingl, J Stephens, ... Cell reports 10 (8), 1239-1245, 2015 | 483 | 2015 |
| Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer YS Ju, LB Alexandrov, M Gerstung, I Martincorena, S Nik-Zainal, ... elife 3, e02935, 2014 | 361 | 2014 |
| Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia E Yankova, W Blackaby, M Albertella, J Rak, E De Braekeleer, ... Nature 593 (7860), 597-601, 2021 | 360 | 2021 |
| Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes S Mueller, T Engleitner, R Maresch, M Zukowska, S Lange, ... Nature 554 (7690), 62-68, 2018 | 324 | 2018 |
| PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice R Rad, L Rad, W Wang, J Cadinanos, G Vassiliou, S Rice, LS Campos, ... Science 330 (6007), 1104-1107, 2010 | 273 | 2010 |
| Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice GS Vassiliou, JL Cooper, R Rad, J Li, S Rice, A Uren, L Rad, P Ellis, ... Nature genetics 43 (5), 470-475, 2011 | 254 | 2011 |
| PPM1D mutations drive clonal hematopoiesis in response to cytotoxic chemotherapy JI Hsu, T Dayaram, A Tovy, E De Braekeleer, M Jeong, F Wang, J Zhang, ... Cell stem cell 23 (5), 700-713. e6, 2018 | 253 | 2018 |
| Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? CS Grove, GS Vassiliou Disease models & mechanisms 7 (8), 941-951, 2014 | 229 | 2014 |
| A genetic progression model of BrafV600E-induced intestinal tumorigenesis reveals targets for therapeutic intervention R Rad, J Cadiñanos, L Rad, I Varela, A Strong, L Kriegl, ... Cancer cell 24 (1), 15-29, 2013 | 212 | 2013 |
| CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice J Weber, R Öllinger, M Friedrich, U Ehmer, M Barenboim, K Steiger, I Heid, ... Proceedings of the National Academy of Sciences 112 (45), 13982-13987, 2015 | 197 | 2015 |
| Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice R Maresch, S Mueller, C Veltkamp, R Öllinger, M Friedrich, I Heid, ... Nature communications 7 (1), 10770, 2016 | 179 | 2016 |
| KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype A Clipson, M Wang, L De Leval, M Ashton-Key, A Wotherspoon, ... Leukemia 29 (5), 1177-1185, 2015 | 171 | 2015 |
| Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia MA Dawson, EJ Gudgin, SJ Horton, G Giotopoulos, E Meduri, S Robson, ... Leukemia 28 (2), 311-320, 2014 | 170 | 2014 |
| Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ... Cancer discovery 6 (10), 1166-1181, 2016 | 167 | 2016 |
Allan BradleyDept of Medicine, Cambridge University, UKПотвърден имейл адрес: cam.ac.uk
