aled edwards
aled edwards
Professor
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Protein production and purification
S Gräslund, P Nordlund, J Weigelt, BM Hallberg, J Bray, O Gileadi, ...
Nature methods 5 (2), 135, 2008
7022008
Architecture of RNA polymerase II and implications for the transcription mechanism
P Cramer, DA Bushnell, J Fu, AL Gnatt, B Maier-Davis, NE Thompson, ...
Science 288 (5466), 640-649, 2000
6722000
Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA
A Bochkarev, RA Pfuetzner, AM Edwards, L Frappier
Nature 385 (6612), 176-181, 1997
5931997
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
5512006
Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
L Chen, I Borozan, J Feld, J Sun, LL Tannis, C Coltescu, J Heathcote, ...
Gastroenterology 128 (5), 1437-1444, 2005
5082005
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
4292015
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
3802011
Structural proteomics of an archaeon
D Christendat, A Yee, A Dharamsi, Y Kluger, A Savchenko, JR Cort, ...
Nature structural biology 7 (10), 903-909, 2000
3802000
Bridging structural biology and genomics: assessing protein interaction data with known complexes
AM Edwards, B Kus, R Jansen, D Greenbaum, J Greenblatt, M Gerstein
TRENDS in Genetics 18 (10), 529-536, 2002
3302002
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1: implications for EBV-mediated immortalization
V Saridakis, Y Sheng, F Sarkari, MN Holowaty, K Shire, T Nguyen, ...
Molecular cell 18 (1), 25-36, 2005
3162005
Herpes simplex virus triggers and then disarms a host antiviral response
KL Mossman, PF Macgregor, JJ Rozmus, AB Goryachev, AM Edwards, ...
Journal of virology 75 (2), 750-758, 2001
2992001
Too many roads not taken
AM Edwards, R Isserlin, GD Bader, SV Frye, TM Willson, HY Frank
Nature 470 (7333), 163-165, 2011
2922011
Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro.
AM Edwards, CM Kane, RA Young, RD Kornberg
Journal of Biological Chemistry 266 (1), 71-75, 1991
2711991
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms
M Vedadi, J Lew, J Artz, M Amani, Y Zhao, A Dong, GA Wasney, M Gao, ...
Molecular and biochemical parasitology 151 (1), 100-110, 2007
2592007
In situ proteolysis for protein crystallization and structure determination
A Dong, X Xu, AM Edwards
Nature methods 4 (12), 1019-1021, 2007
2542007
The Drosophila nuclear receptor e75 contains heme and is gas responsive
J Reinking, MMS Lam, K Pardee, HM Sampson, S Liu, P Yang, S Williams, ...
Cell 122 (2), 195-207, 2005
2502005
Crystal structure of the CorA Mg 2+ transporter
VV Lunin, E Dobrovetsky, G Khutoreskaya, R Zhang, A Joachimiak, ...
Nature 440 (7085), 833-837, 2006
2452006
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA
G Mer, A Bochkarev, R Gupta, E Bochkareva, L Frappier, CJ Ingles, ...
Cell 103 (3), 449-456, 2000
2442000
A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair
M Babu, N Beloglazova, R Flick, C Graham, T Skarina, B Nocek, ...
Molecular microbiology 79 (2), 484-502, 2011
2412011
Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family
E Kuznetsova, M Proudfoot, CF Gonzalez, G Brown, MV Omelchenko, ...
Journal of Biological Chemistry 281 (47), 36149-36161, 2006
2372006
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