Следене
Luis Alejandro Rojas
Luis Alejandro Rojas
Director, Lead Generation at Ananke Therapeutics
Потвърден имейл адрес: ananketx.com
Заглавие
Позовавания
Позовавания
Година
The C-terminal domain of RNA polymerase II is modified by site-specific methylation
RJ Sims III, LA Rojas, D Beck, R Bonasio, R Schüller, WJ Drury III, D Eick, ...
Science 332 (6025), 99-103, 2011
2612011
Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30
K Liu, Y Guo, H Liu, C Bian, R Lam, Y Liu, F Mackenzie, LA Rojas, ...
PloS one 7 (2), e30375, 2012
1032012
A diagnostic oligonucleotide microarray for simultaneous detection of grapevine viruses
EA Engel, PF Escobar, LA Rojas, PA Rivera, N Fiore, PDT Valenzuela
Journal of Virological Methods 163 (2), 445-451, 2010
912010
Co-repressor CBFA2T2 regulates pluripotency and germline development
S Tu, V Narendra, M Yamaji, SE Vidal, LA Rojas, X Wang, SY Kim, ...
Nature 534 (7607), 387-390, 2016
702016
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes
E Lecona, LA Rojas, R Bonasio, A Johnston, O Fernández-Capetillo, ...
PLoS biology 11 (12), e1001737, 2013
382013
p38α regulates expression of DUX4 in a model of facioscapulohumeral muscular dystrophy
LA Rojas, E Valentine, A Accorsi, J Maglio, N Shen, A Robertson, ...
Journal of Pharmacology and Experimental Therapeutics 374 (3), 489-498, 2020
332020
Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy
AL Mueller, A O'Neill, TI Jones, A Llach, LA Rojas, P Sakellariou, ...
Experimental neurology 320, 113011, 2019
262019
Analysis of manganese-regulated gene expression in the ligninolytic basidiomycete Ceriporiopsis subvermispora
M Gutiérrez, LA Rojas, R Mancilla-Villalobos, D Seelenfreund, R Vicuña, ...
Current genetics 54, 163-173, 2008
102008
Analysis of the intronic single nucleotide polymorphism rs# 466452 of the nephrin gene in patients with diabetic nephropathy
R González, A Tirado, LA Rojas, FJ Ossandón, M Alvo, C Wolff, ...
Biological Research 42 (2), 189-198, 2009
62009
Spatially coordinated heterochromatinization of distal short tandem repeats in fragile X syndrome
L Zhou, C Ge, T Malachowski, JH Kim, KR Chandradoss, C Su, H Wu, ...
bioRxiv, 2021.04. 23.441217, 2021
52021
Design of a phase 2, randomized, double-blind, placebo-controlled, 24-week, parallel-group study of the efficacy and safety of losmapimod in treating subjects with …
A Tawil, M Mellion, L Ronco, S Raines, W Tracewell, A Rahilly, A Rojas, ...
Neurology 94 (15 Supplement), 2020
52020
Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial
R Tawil, KR Wagner, JI Hamel, DG Leung, JM Statland, LH Wang, ...
The Lancet Neurology 23 (5), 477-486, 2024
22024
Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
T Malachowski, KR Chandradoss, R Boya, L Zhou, AL Cook, C Su, ...
Cell 186 (26), 5840-5858. e36, 2023
12023
A phase 2, randomized, double-blind, placebo-controlled, 48-week study of the efficacy and safety of losmapimod in subjects with FSHD: ReDUX4 (S23. 007)
R Tawil, J Statland, L Wang, A Genge, S Sacconi, H Lochmuller, DR Leiva, ...
Neurology 98 (18 Supplement), 2022
12022
Elevated α-synuclein attenuates phagocytosis in SNCA triplication human iPSC-derived neuron:microglia co-cultures
R Lieberman, K Elnaggar, K Jesseman, S DeFrancisco, K Degouveia, ...
bioRxiv, 2022.11. 15.516591, 2022
2022
Reachable Workspace to Evaluate Efficacy of Losmapimod in Subjects with FSHD in Two Phase 2 Studies (P4-13.008)
M Mellion, J Han, J Shoskes, R Tawil, J Statland, L Wang, A Genge, ...
Neurology 98 (18 Supplement), 2022
2022
Whole Body MRI Quantitative muscle analysis to evaluate Efficacy of Losmapimod in a Phase 2 Placebo-Controlled Study in Subjects with FSHD (ReDUX4)(S23. 009)
M Mellion, R Tawil, J Statland, L Wang, A Genge, S Sacconi, ...
Neurology 98 (18 Supplement), 2022
2022
Revolutionizing drug discovery in genetically-defined muscle disease using single-cell and high dimensional datasets
L Rojas, A Ergun, A Accorsi, C Sartain, A Raman, R Lieberman, ...
NEUROMUSCULAR DISORDERS 31, S147-S147, 2021
2021
A Biomarker of DUX4 Activity to Evaluate losmapimod Treatment Effect in FSHD Phase 2 Trials (4747)
L Ronco, P Shieh, A Tawil, K Wagner, J Statland, J Chadchankar, ...
Neurology 94 (15 Supplement), 2020
2020
Pharmacologic modulation of DUX4-dependent phenotypes in FSHD
L Rojas, A Accorsi, N Shen, J Maglio, A Chang, P Rahl, A Cacace
Neuromuscular Disorders 27, S200, 2017
2017
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Статии 1–20