| Phenomenon of optical self-purification of chiral non-racemic compounds VA Soloshonok, H Ueki, M Yasumoto, S Mekala, JS Hirschi, DA Singleton Journal of the American Chemical Society 129 (40), 12112-12113, 2007 | 189 | 2007 |
| Boosting NAD+ with a small molecule that activates NAMPT SJ Gardell, M Hopf, A Khan, M Dispagna, E Hampton Sessions, R Falter, ... Nature communications 10 (1), 3241, 2019 | 127 | 2019 |
| Recrossing and dynamic matching effects on selectivity in a Diels-Alder reaction Z Wang, JS Hirschi, DA Singleton Angewandte Chemie (International ed. in English) 48 (48), 9156, 2009 | 119 | 2009 |
| Insights into the Mechanism of Flavoprotein-Catalyzed Amine Oxidation from Nitrogen Isotope Effects on the Reaction of N-Methyltryptophan Oxidase EC Ralph, JS Hirschi, MA Anderson, WW Cleland, DA Singleton, ... Biochemistry 46 (25), 7655-7664, 2007 | 86 | 2007 |
| Newtonian kinetic isotope effects. Observation, prediction, and origin of heavy-atom dynamic isotope effects KK Kelly, JS Hirschi, DA Singleton Journal of the American Chemical Society 131 (24), 8382-8383, 2009 | 74 | 2009 |
| A general approach to convert hemicyanine dyes into highly optimized photoacoustic scaffolds for analyte sensing SH Gardner, CJ Brady, C Keeton, AK Yadav, SC Mallojjala, MY Lucero, ... Angewandte Chemie International Edition 60 (34), 18860-18866, 2021 | 71 | 2021 |
| Transition-State Geometry Measurements from 13C Isotope Effects. The Experimental Transition State for the Epoxidation of Alkenes with Oxaziridines JS Hirschi, T Takeya, C Hang, DA Singleton Journal of the American Chemical Society 131 (6), 2397-2403, 2009 | 69 | 2009 |
| Stereoselective reactions of ortho-quinone methide and ortho-quinone methide imines and their utility in natural product synthesis CDT Nielsen, H Abas, AC Spivey Synthesis 50 (20), 4008-4018, 2018 | 64 | 2018 |
| Catalytic enantioselective synthesis of lactams through formal [4+ 2] cycloaddition of imines with homophthalic anhydride CL Jarvis, JS Hirschi, MJ Vetticatt, D Seidel Angewandte Chemie International Edition 56 (10), 2670-2674, 2017 | 60 | 2017 |
| Formation of hydrazones and stabilized boron–nitrogen heterocycles in aqueous solution from carbohydrazides and ortho-formylphenylboronic acids H Gu, TI Chio, Z Lei, RJ Staples, JS Hirschi, S Bane Organic & Biomolecular Chemistry 15 (36), 7543-7548, 2017 | 55 | 2017 |
| Asymmetric Induction via a Helically Chiral Anion: Enantioselective Pentacarboxycyclopentadiene Brønsted Acid-Catalyzed Inverse-Electron-Demand Diels–Alder Cycloaddition of … CD Gheewala, JS Hirschi, WH Lee, DW Paley, MJ Vetticatt, TH Lambert Journal of the American Chemical Society 140 (10), 3523-3527, 2018 | 54 | 2018 |
| A selenourea-thiourea Brønsted acid catalyst facilitates asymmetric conjugate additions of amines to α, β-unsaturated esters Y Lin, WJ Hirschi, A Kunadia, A Paul, I Ghiviriga, KA Abboud, RW Karugu, ... Journal of the American Chemical Society 142 (12), 5627-5635, 2020 | 50 | 2020 |
| Biocatalytic, intermolecular C− H bond functionalization for the synthesis of enantioenriched amides SV Athavale, S Gao, Z Liu, SC Mallojjala, JS Hirschi, FH Arnold Angewandte Chemie 133 (47), 25068-25073, 2021 | 46 | 2021 |
| Enzymatic nitrogen insertion into unactivated C–H bonds SV Athavale, S Gao, A Das, SC Mallojjala, E Alfonzo, Y Long, JS Hirschi, ... Journal of the American Chemical Society 144 (41), 19097-19105, 2022 | 43 | 2022 |
| The Normal Range for Secondary Swain− Schaad Exponents without Tunneling or Kinetic Complexity J Hirschi, DA Singleton Journal of the American Chemical Society 127 (10), 3294-3295, 2005 | 41 | 2005 |
| Isotope Effects Reveal the Mechanism of Enamine Formation in l-Proline-Catalyzed α-Amination of Aldehydes MA Ashley, JS Hirschi, JA Izzo, MJ Vetticatt Journal of the American Chemical Society 138 (6), 1756-1759, 2016 | 39 | 2016 |
| Exo-Selective Diels− Alder Reactions of Vinylazepines. Origin of Divergent Stereoselectivity in Diels− Alder Reactions of Vinylazepines, Vinylpiperideines, and Vinylcycloalkenes B Boren, JS Hirschi, JH Reibenspies, MD Tallant, DA Singleton, ... The Journal of Organic Chemistry 68 (23), 8991-8995, 2003 | 36 | 2003 |
| A designed approach to enantiodivergent enamine catalysis J Macharia, V Wambua, Y Hong, L Harris, JS Hirschi, GB Evans, ... Angewandte Chemie 129 (30), 8882-8886, 2017 | 32 | 2017 |
| Transition states of native and drug-resistant HIV-1 protease are the same DR Kipp, JS Hirschi, A Wakata, H Goldstein, VL Schramm Proceedings of the National Academy of Sciences 109 (17), 6543-6548, 2012 | 32 | 2012 |
| Asymmetric dihydroxylation of allenes SA Fleming, SM Carroll, J Hirschi, R Liu, JL Pace, JT Redd Tetrahedron letters 45 (17), 3341-3343, 2004 | 29 | 2004 |
