Следене
Ruth Brenk
Ruth Brenk
Потвърден имейл адрес: uib.no
Заглавие
Позовавания
Позовавания
Година
Lessons learnt from assembling screening libraries for drug discovery for neglected diseases
R Brenk, A Schipani, D James, A Krasowski, IH Gilbert, J Frearson, ...
ChemMedChem 3 (3), 435-444, 2008
5462008
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ...
Nature 464 (7289), 728, 2010
3152010
Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry
VT Bhat, AM Caniard, T Luksch, R Brenk, DJ Campopiano, MF Greaney
Nature Chemistry 2 (6), 490-497, 2010
2172010
Decoys for docking
AP Graves, R Brenk, BK Shoichet
Journal of medicinal chemistry 48 (11), 3714-3728, 2005
1462005
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis
R Brenk, L Naerum, U Grädler, HD Gerber, GA Garcia, K Reuter, ...
Journal of medicinal chemistry 46 (7), 1133-1143, 2003
1282003
Design, synthesis, and biological evaluation of 3, 4-diarylmaleimides as angiogenesis inhibitors
C Peifer, T Stoiber, E Unger, F Totzke, C Schächtele, D Marmé, R Brenk, ...
Journal of medicinal chemistry 49 (4), 1271-1281, 2006
1232006
Nucleosomes can invade DNA territories occupied by their neighbors
M Engeholm, M de Jager, A Flaus, R Brenk, J van Noort, T Owen-Hughes
Nature structural & molecular biology 16 (2), 151-158, 2009
1222009
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors
S Brand, LAT Cleghorn, SP McElroy, DA Robinson, VC Smith, ...
Journal of medicinal chemistry 55 (1), 140-152, 2011
1152011
Novel ligands for a purine riboswitch discovered by RNA-ligand docking
P Daldrop, FE Reyes, DA Robinson, CM Hammond, DM Lilley, RT Batey, ...
Chemistry & biology 18 (3), 324-335, 2011
1152011
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening
CP Mpamhanga, D Spinks, LB Tulloch, EJ Shanks, DA Robinson, ...
Journal of medicinal chemistry 52 (14), 4454-4465, 2009
1112009
DrugPred: a structure-based approach to predict protein druggability developed using an extensive nonredundant data set
A Krasowski, D Muthas, A Sarkar, S Schmitt, R Brenk
Journal of chemical information and modeling 51 (11), 2829-2842, 2011
982011
Probing molecular docking in a charged model binding site
R Brenk, SW Vetter, SE Boyce, DB Goodin, BK Shoichet
Journal of molecular biology 357 (5), 1449-1470, 2006
862006
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation …
B Stengl, EA Meyer, A Heine, R Brenk, F Diederich, G Klebe
Journal of molecular biology 370 (3), 492-511, 2007
732007
Riboswitches as Drug Targets for Antibiotics
V Panchal, R Brenk
Antibiotics 10 (1), 45, 2021
672021
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments
R Urich, G Wishart, M Kiczun, A Richters, N Tidten-Luksch, D Rauh, ...
ACS chemical biology 8 (5), 1044-1052, 2013
652013
Identification of Inhibitors of the Leishmania cdc2‐Related Protein Kinase CRK3
LAT Cleghorn, A Woodland, IT Collie, LS Torrie, N Norcross, T Luksch, ...
ChemMedChem 6 (12), 2214-2224, 2011
622011
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as …
S Brand, NR Norcross, S Thompson, JR Harrison, VC Smith, ...
Journal of medicinal chemistry 57 (23), 9855-9869, 2014
612014
Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library
NY Mok, R Brenk
Journal of chemical information and modeling 51 (10), 2449-2454, 2011
572011
Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa
MS Alphey, L Pirrie, LS Torrie, WA Boulkeroua, M Gardiner, A Sarkar, ...
ACS chemical biology 8 (2), 387-396, 2012
532012
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1
D Spinks, HB Ong, CP Mpamhanga, EJ Shanks, DA Robinson, IT Collie, ...
ChemMedChem 6 (2), 302-308, 2011
522011
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