Следене
Linjie Han
Linjie Han
Principle Research Scientist, Process and Product Characterization (Biologics), AbbVie
Няма потвърден имейл адрес - Начална страница
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Позовавания
Позовавания
Година
Collision induced unfolding of intact antibodies: rapid characterization of disulfide bonding patterns, glycosylation, and structures
Y Tian, L Han, AC Buckner, BT Ruotolo
Analytical chemistry 87 (22), 11509-11515, 2015
1732015
Collisional and Coulombic unfolding of gas‐phase proteins: high correlation to their domain structures in solution
Y Zhong, L Han, BT Ruotolo
Angewandte Chemie 126 (35), 9363-9366, 2014
1622014
Bound anions differentially stabilize multiprotein complexes in the absence of bulk solvent
L Han, SJ Hyung, JJS Mayers, BT Ruotolo
Journal of the American Chemical Society 133 (29), 11358-11367, 2011
1142011
Bound cations significantly stabilize the structure of multiprotein complexes in the gas-phase
L Han, SJ Hyung, BT Ruotolo
Angewandte Chemie (International ed. in English) 51 (23), 5692, 2012
712012
High-throughput multi-attribute analysis of antibody-drug conjugates enabled by trapped ion mobility spectrometry and top-down mass spectrometry
EJ Larson, DS Roberts, JA Melby, KM Buck, Y Zhu, S Zhou, L Han, ...
Analytical chemistry 93 (29), 10013-10021, 2021
322021
Ion mobility-mass spectrometry differentiates protein quaternary structures formed in solution and in electrospray droplets
L Han, BT Ruotolo
Analytical chemistry 87 (13), 6808-6813, 2015
292015
Hofmeister salts recover a misfolded multiprotein complex for subsequent structural measurements in the gas phase
L Han, BT Ruotolo
Angewandte Chemie (International ed. in English) 52 (32), 8329, 2013
282013
Traveling-wave ion mobility-mass spectrometry reveals additional mechanistic details in the stabilization of protein complex ions through tuned salt additives
L Han, BT Ruotolo
International Journal for Ion Mobility Spectrometry 16, 41-50, 2013
282013
Synthesis, characterization, DNA-binding and DNA-photocleavage studies of [Ru (bpy) 2 (pmip)] 2+ and [Ru (phen) 2 (pmip)] 2+(pmip= 2-(2′-pyrimidyl) imidazo [4, 5-f][1, 10 …
S Shi, T Xie, TM Yao, CR Wang, XT Geng, DJ Yang, LJ Han, LN Ji
Polyhedron 28 (7), 1355-1361, 2009
282009
Automated capillary isoelectric focusing-mass spectrometry with ultrahigh resolution for characterizing microheterogeneity and isoelectric points of intact protein complexes
T Xu, L Han, L Sun
Analytical Chemistry 94 (27), 9674-9682, 2022
232022
Analysis of a Soluble (UreD:UreF:UreG)2 Accessory Protein Complex and Its Interactions with Klebsiella aerogenes Urease by Mass Spectrometry
MA Farrugia, L Han, Y Zhong, JL Boer, BT Ruotolo, RP Hausinger
Journal of The American Society for Mass Spectrometry 24 (9), 1328-1337, 2013
212013
Dramatically stabilizing multiprotein complex structure in the absence of bulk water using tuned Hofmeister salts
L Han, SJ Hyung, BT Ruotolo
Faraday discussions 160, 371-388, 2013
202013
An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants
T Xu, L Han, AMG Thompson, L Sun
Analytical Methods 14 (4), 383-393, 2022
162022
Impact of linker-drug on ion exchange chromatography separation of antibody-drug conjugates
Z Zhang, S Zhou, L Han, Q Zhang, WA Pritts
Mabs 11 (6), 1113-1121, 2019
102019
Flavonoids inhibit heparin-induced aggregation of the third repeat (r3) of microtubule-binding domain of alzheimer’s tau protein
LJ Han, S Shi, LF Zheng, DJ Yang, TM Yao, LN Ji
Bulletin of the Chemical Society of Japan 83 (8), 911-922, 2010
102010
Rapid analysis of reduced antibody drug conjugate by online LC-MS/MS with fourier transform Ion cyclotron resonance mass spectrometry
EJ Larson, Y Zhu, Z Wu, B Chen, Z Zhang, S Zhou, L Han, Q Zhang, Y Ge
Analytical chemistry 92 (22), 15096-15103, 2020
92020
Conjugation Site Analysis by MS/MS Protein Sequencing
L Han, Y Zhao, Q Zhang
Antibody-Drug Conjugates: Methods and Protocols, 221-233, 2020
22020
Selective Reduction of Cysteine Mutant Antibodies for Site-Specific Antibody–Drug Conjugates
X Liao, A Haight, D Welch, L Han
Bioconjugate Chemistry 34 (12), 2293-2301, 2023
12023
Developing Ion Mobility-Mass Spectrometry for Measurements of Solution-Relevant Protein Structures.
L Han
2014
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Статии 1–19