Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells CB Mellough, E Sernagor, I Moreno-Gimeno, DHW Steel, M Lako Stem cells 30 (4), 673-686, 2012 | 200 | 2012 |
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-Jovin, D Dolan, ... Nature communications 9 (1), 4234, 2018 | 191 | 2018 |
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development NC Hunt, D Hallam, A Karimi, CB Mellough, J Chen, DHW Steel, M Lako Acta biomaterialia 49, 329-343, 2017 | 165 | 2017 |
IGF-1 signaling plays an important role in the formation of three-dimensional laminated neural retina and other ocular structures from human embryonic stem cells CB Mellough, J Collin, M Khazim, K White, E Sernagor, DHW Steel, ... Stem cells 33 (8), 2416-2430, 2015 | 158 | 2015 |
Gene therapy and transplantation in CNS repair: the visual system AR Harvey, Y Hu, SG Leaver, CB Mellough, K Park, J Verhaagen, ... Progress in retinal and eye research 25 (5), 449-489, 2006 | 153 | 2006 |
Retinal pigment epithelium and age‐related macular degeneration: a review of major disease mechanisms S Somasundaran, IJ Constable, CB Mellough, LS Carvalho Clinical & Experimental Ophthalmology 48 (8), 1043-1056, 2020 | 129 | 2020 |
An integrated transcriptional analysis of the developing human retina CB Mellough, R Bauer, J Collin, B Dorgau, D Zerti, DWP Dolan, CM Jones, ... Development 146 (2), dev169474, 2019 | 89 | 2019 |
Systematic comparison of retinal organoid differentiation from human pluripotent stem cells reveals stage specific, cell line, and methodological differences CB Mellough, J Collin, R Queen, G Hilgen, B Dorgau, D Zerti, ... Stem cells translational medicine 8 (7), 694-706, 2019 | 86 | 2019 |
An induced pluripotent stem cell patient specific model of complement factor H (Y402H) polymorphism displays characteristic features of age-related macular degeneration and … D Hallam, J Collin, S Bojic, V Chichagova, A Buskin, Y Xu, L Lafage, ... Stem Cells 35 (11), 2305-2320, 2017 | 68 | 2017 |
CRX expression in pluripotent stem cell-derived photoreceptors marks a transplantable subpopulation of early cones J Collin, D Zerti, R Queen, T Santos-Ferreira, R Bauer, J Coxhead, ... Stem Cells 37 (5), 609-622, 2019 | 66 | 2019 |
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models R Megaw, H Abu-Arafeh, M Jungnickel, C Mellough, C Gurniak, W Witke, ... Nature Communications 8 (1), 271, 2017 | 65 | 2017 |
Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells CB Mellough, Q Cui, KL Spalding, NA Symons, MA Pollett, EY Snyder, ... Experimental neurology 186 (1), 6-19, 2004 | 60 | 2004 |
Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular OG Izuogu, AA Alhasan, C Mellough, J Collin, R Gallon, J Hyslop, ... BMC genomics 19, 1-18, 2018 | 52 | 2018 |
Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 … M Felemban, B Dorgau, NC Hunt, D Hallam, D Zerti, R Bauer, Y Ding, ... Acta biomaterialia 74, 207-221, 2018 | 46 | 2018 |
Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell … CB Mellough, Q Cui, AR Harvey Restorative neurology and neuroscience 25 (2), 177-190, 2007 | 45 | 2007 |
Using zinc finger nuclease technology to generate CRX-reporter human embryonic stem cells as a tool to identify and study the emergence of photoreceptors precursors during … J Collin, CB Mellough, B Dorgau, S Przyborski, I Moreno-Gimeno, M Lako Stem Cells 34 (2), 311-321, 2016 | 39 | 2016 |
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation B Dorgau, M Felemban, A Sharpe, R Bauer, D Hallam, DH Steel, ... Cell death & disease 9 (6), 615, 2018 | 29 | 2018 |
A review of gene, drug and cell-based therapies for Usher syndrome LS French, CB Mellough, FK Chen, LS Carvalho Frontiers in Cellular Neuroscience 14, 183, 2020 | 25 | 2020 |
Lab generated retina: Realizing the dream CB Mellough, J Collin, E Sernagor, NK Wride, DHW Steel, M Lako Visual neuroscience 31 (4-5), 317-332, 2014 | 23 | 2014 |
Genetic basis of inherited macular dystrophies and implications for stem cell therapy CB Mellough, DHW Steel, M Lako Stem cells 27 (11), 2833-2845, 2009 | 19 | 2009 |