| Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data BO Bachmann, J Ravel Methods in enzymology 458, 181-217, 2009 | 415* | 2009 |
| A genomics-guided approach for discovering and expressing cryptic metabolic pathways E Zazopoulos, K Huang, A Staffa, W Liu, BO Bachmann, K Nonaka, ... Nature biotechnology 21 (2), 187-190, 2003 | 397 | 2003 |
| The calicheamicin gene cluster and its iterative type I enediyne PKS J Ahlert, E Shepard, N Lomovskaya, E Zazopoulos, A Staffa, ... Science 297 (5584), 1173-1176, 2002 | 360 | 2002 |
| Microbial genome mining for accelerated natural products discovery: is a renaissance in the making? BO Bachmann, SG Van Lanen, RH Baltz Journal of industrial Microbiology and Biotechnology 41 (2), 175-184, 2014 | 292 | 2014 |
| Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example JB McAlpine, BO Bachmann, M Piraee, S Tremblay, AM Alarco, ... Journal of natural products 68 (4), 493-496, 2005 | 287 | 2005 |
| Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities J Zhou, WL Kelly, BO Bachmann, M Gunsior, CA Townsend, EI Solomon Journal of the American Chemical Society 123 (30), 7388-7398, 2001 | 194 | 2001 |
| The IsdG‐family of haem oxygenases degrades haem to a novel chromophore ML Reniere, GN Ukpabi, SR Harry, DF Stec, R Krull, DW Wright, ... Molecular microbiology 75 (6), 1529-1538, 2010 | 159 | 2010 |
| β-Lactam synthetase: a new biosynthetic enzyme BO Bachmann, R Li, CA Townsend Proceedings of the National Academy of Sciences 95 (16), 9082-9086, 1998 | 143 | 1998 |
| Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites BC Covington, JA McLean, BO Bachmann Natural Product Reports 34 (1), 6-24, 2017 | 134 | 2017 |
| Benzodiazepine biosynthesis in Streptomyces refuineus Y Hu, V Phelan, I Ntai, CM Farnet, E Zazopoulos, BO Bachmann Chemistry & biology 14 (6), 691-701, 2007 | 120 | 2007 |
| Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: coupling mechanism of oxidative decarboxylation and hydroxylation J Zhou, M Gunsior, BO Bachmann, CA Townsend, EI Solomon Journal of the American Chemical Society 120 (51), 13539-13540, 1998 | 120 | 1998 |
| Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism DK Derewacz, CR Goodwin, CR McNees, JA McLean, BO Bachmann Proceedings of the National Academy of Sciences 110 (6), 2336-2341, 2013 | 98 | 2013 |
| 7-Alkylidenecephalosporin esters as inhibitors of human leukocyte elastase JD Buynak, AS Rao, GP Ford, C Carver, G Adam, B Geng, B Bachmann, ... Journal of medicinal chemistry 40 (21), 3423-3433, 1997 | 90 | 1997 |
| Mapping microbial response metabolomes for induced natural product discovery DK Derewacz, BC Covington, JA McLean, BO Bachmann ACS chemical biology 10 (9), 1998-2006, 2015 | 87 | 2015 |
| Structure of β-lactam synthetase reveals how to synthesize antibiotics instead of asparagine MT Miller, BO Bachmann, CA Townsend, AC Rosenzweig Nature structural biology 8 (8), 684-689, 2001 | 87 | 2001 |
| Synthesis and biological activity of 7-alkylidenecephems JD Buynak, K Wu, B Bachmann, D Khasnis, L Hua, HK Nguyen, ... Journal of medicinal chemistry 38 (6), 1022-1034, 1995 | 85 | 1995 |
| Bioactive oligosaccharide natural products EK McCranie, BO Bachmann Natural product reports 31 (8), 1026-1042, 2014 | 84 | 2014 |
| Lipophilic mediated assays for β-hematin inhibitors MD Carter, VV Phelan, RD Sandlin, BO Bachmann, DW Wright Combinatorial chemistry & high throughput screening 13 (3), 285-292, 2010 | 77 | 2010 |
| Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis DP Nannemann, WR Birmingham, RA Scism, BO Bachmann Future medicinal chemistry 3 (7), 809-819, 2011 | 70 | 2011 |
| The catalytic cycle of β-lactam synthetase observed by x-ray crystallographic snapshots MT Miller, BO Bachmann, CA Townsend, AC Rosenzweig Proceedings of the National Academy of Sciences 99 (23), 14752-14757, 2002 | 67 | 2002 |
