Brian O. Bachmann
Brian O. Bachmann
Associate Professor of Chemistry, Vanderbilt University
Потвърден имейл адрес: vanderbilt.edu
Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
BO Bachmann, J Ravel
Methods in enzymology 458, 181-217, 2009
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
E Zazopoulos, K Huang, A Staffa, W Liu, BO Bachmann, K Nonaka, ...
Nature biotechnology 21 (2), 187-190, 2003
The calicheamicin gene cluster and its iterative type I enediyne PKS
J Ahlert, E Shepard, N Lomovskaya, E Zazopoulos, A Staffa, ...
Science 297 (5584), 1173-1176, 2002
Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
BO Bachmann, SG Van Lanen, RH Baltz
Journal of industrial Microbiology and Biotechnology 41 (2), 175-184, 2014
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example
JB McAlpine, BO Bachmann, M Piraee, S Tremblay, AM Alarco, ...
Journal of natural products 68 (4), 493-496, 2005
Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities
J Zhou, WL Kelly, BO Bachmann, M Gunsior, CA Townsend, EI Solomon
Journal of the American Chemical Society 123 (30), 7388-7398, 2001
The IsdG‐family of haem oxygenases degrades haem to a novel chromophore
ML Reniere, GN Ukpabi, SR Harry, DF Stec, R Krull, DW Wright, ...
Molecular microbiology 75 (6), 1529-1538, 2010
β-Lactam synthetase: a new biosynthetic enzyme
BO Bachmann, R Li, CA Townsend
Proceedings of the National Academy of Sciences 95 (16), 9082-9086, 1998
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
BC Covington, JA McLean, BO Bachmann
Natural Product Reports 34 (1), 6-24, 2017
Benzodiazepine biosynthesis in Streptomyces refuineus
Y Hu, V Phelan, I Ntai, CM Farnet, E Zazopoulos, BO Bachmann
Chemistry & biology 14 (6), 691-701, 2007
Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: coupling mechanism of oxidative decarboxylation and hydroxylation
J Zhou, M Gunsior, BO Bachmann, CA Townsend, EI Solomon
Journal of the American Chemical Society 120 (51), 13539-13540, 1998
Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism
DK Derewacz, CR Goodwin, CR McNees, JA McLean, BO Bachmann
Proceedings of the National Academy of Sciences 110 (6), 2336-2341, 2013
7-Alkylidenecephalosporin esters as inhibitors of human leukocyte elastase
JD Buynak, AS Rao, GP Ford, C Carver, G Adam, B Geng, B Bachmann, ...
Journal of medicinal chemistry 40 (21), 3423-3433, 1997
Mapping microbial response metabolomes for induced natural product discovery
DK Derewacz, BC Covington, JA McLean, BO Bachmann
ACS chemical biology 10 (9), 1998-2006, 2015
Structure of β-lactam synthetase reveals how to synthesize antibiotics instead of asparagine
MT Miller, BO Bachmann, CA Townsend, AC Rosenzweig
Nature structural biology 8 (8), 684-689, 2001
Synthesis and biological activity of 7-alkylidenecephems
JD Buynak, K Wu, B Bachmann, D Khasnis, L Hua, HK Nguyen, ...
Journal of medicinal chemistry 38 (6), 1022-1034, 1995
Bioactive oligosaccharide natural products
EK McCranie, BO Bachmann
Natural product reports 31 (8), 1026-1042, 2014
Lipophilic mediated assays for β-hematin inhibitors
MD Carter, VV Phelan, RD Sandlin, BO Bachmann, DW Wright
Combinatorial chemistry & high throughput screening 13 (3), 285-292, 2010
Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis
DP Nannemann, WR Birmingham, RA Scism, BO Bachmann
Future medicinal chemistry 3 (7), 809-819, 2011
The catalytic cycle of β-lactam synthetase observed by x-ray crystallographic snapshots
MT Miller, BO Bachmann, CA Townsend, AC Rosenzweig
Proceedings of the National Academy of Sciences 99 (23), 14752-14757, 2002
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