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Ian Barrett
Ian Barrett
Senior Director, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
The DNA sequence of the human X chromosome
MT Ross, DV Grafham, AJ Coffey, S Scherer, K McLay, D Muzny, ...
Nature 434 (7031), 325-337, 2005
13922005
Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway
RJ Mills, BL Parker, GA Quaife-Ryan, HK Voges, EJ Needham, A Bornot, ...
Cell stem cell 24 (6), 895-907. e6, 2019
2512019
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ...
Science advances 4 (6), eaat1719, 2018
2462018
A review of biomedical datasets relating to drug discovery: a knowledge graph perspective
S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, A Bender, CT Hoyt, ...
Briefings in Bioinformatics 23 (6), bbac404, 2022
842022
Orally bioavailable and blood–brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice
J Karlin, J Allen, SF Ahmad, G Hughes, V Sheridan, R Odedra, ...
Molecular cancer therapeutics 17 (8), 1637-1647, 2018
582018
Understanding cytotoxicity and cytostaticity in a high-throughput screening collection
LH Mervin, Q Cao, IP Barrett, MA Firth, D Murray, L McWilliams, ...
ACS chemical biology 11 (11), 3007-3023, 2016
572016
Understanding the performance of knowledge graph embeddings in drug discovery
S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, CT Hoyt, WL Hamilton
Artificial Intelligence in the Life Sciences 2, 100036, 2022
502022
Orthologue chemical space and its influence on target prediction
LH Mervin, KC Bulusu, L Kalash, AM Afzal, F Svensson, MA Firth, I Barrett, ...
Bioinformatics 34 (1), 72-79, 2018
422018
Comparison of chemical structure and cell morphology information for multitask bioactivity predictions
MA Trapotsi, LH Mervin, AM Afzal, N Sturm, O Engkvist, IP Barrett, ...
Journal of chemical information and modeling 61 (3), 1444-1456, 2021
352021
Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature
MA Trapotsi, E Mouchet, G Williams, T Monteverde, K Juhani, R Turkki, ...
ACS Chemical Biology 17 (7), 1733-1744, 2022
332022
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC)
F Hoffman, D Gavaghan, J Osborne, IP Barrett, T You, H Ghadially, ...
Journal of Theoretical Biology 436, 39-50, 2018
292018
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
LA Woo, S Tkachenko, M Ding, AT Plowright, O Engkvist, H Andersson, ...
Journal of molecular and cellular cardiology 127, 204-214, 2019
252019
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach
L Drowley, J McPheat, A Nordqvist, S Peel, U Karlsson, S Martinsson, ...
Stem cells translational medicine 9 (1), 47-60, 2020
232020
Automatic extraction of angiogenesis bioprocess from text
X Wang, I McKendrick, I Barrett, I Dix, T French, J Tsujii, S Ananiadou
Bioinformatics 27 (19), 2730-2737, 2011
202011
Implications of topological imbalance for representation learning on biomedical knowledge graphs
S Bonner, U Kirik, O Engkvist, J Tang, IP Barrett
Briefings in bioinformatics 23 (5), bbac279, 2022
192022
Signaling dynamics regulating crosstalks between T-cell activation and immune checkpoints
M Kreileder, I Barrett, C Bendtsen, D Brennan, W Kolch
Trends in cell biology 31 (3), 224-235, 2021
192021
Probabilistic Random Forest improves bioactivity predictions close to the classification threshold by taking into account experimental uncertainty
LH Mervin, MA Trapotsi, AM Afzal, IP Barrett, A Bender, O Engkvist
Journal of Cheminformatics 13, 1-17, 2021
132021
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv. 2018; 4 (6): eaat1719
ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ...
Article PubMed PubMed Central CAS, 2022
112022
New associations between drug-induced adverse events in animal models and humans reveal novel candidate safety targets
KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, ...
Chemical Research in Toxicology 34 (2), 438-451, 2020
102020
Cancer genome analysis informatics
IP Barrett
Genetic Variation: Methods and Protocols, 75-102, 2010
102010
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