Следене
Severin Lechner
Severin Lechner
Потвърден имейл адрес: tum.de
Заглавие
Позовавания
Позовавания
Година
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
S Lechner, MIP Malgapo, C Grätz, RR Steimbach, A Baron, P Rüther, ...
Nature chemical biology 18 (8), 812-820, 2022
472022
Decrypting drug actions and protein modifications by dose-and time-resolved proteomics
J Zecha, FP Bayer, S Wiechmann, J Woortman, N Berner, J Müller, ...
Science 380 (6640), 93-101, 2023
242023
Aza-SAHA derivatives are selective histone deacetylase 10 chemical probes that inhibit polyamine deacetylation and phenocopy HDAC10 knockout
RR Steimbach, CJ Herbst-Gervasoni, S Lechner, TM Stewart, G Klinke, ...
Journal of the American Chemical Society 144 (41), 18861-18875, 2022
132022
Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid
S Lechner, RR Steimbach, L Wang, ML Deline, YC Chang, T Fromme, ...
Nature Communications 14 (1), 3548, 2023
62023
Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition
C Glas, E Naydenova, S Lechner, N Wössner, L Yang, JCB Dietschreit, ...
European Journal of Medicinal Chemistry 240, 114594, 2022
42022
A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics
J Tüshaus, A Sakhteman, S Lechner, M The, E Mucha, C Krisp, J Schlegel, ...
The EMBO Journal 42 (23), e114665, 2023
32023
Targeting LC3/GABARAP for degrader development and autophagy modulation
MP Schwalm, J Dopfer, A Kumar, FA Greco, N Bauer, F Loehr, J Heering, ...
bioRxiv, 2023.10. 05.560930, 2023
12023
High-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells
J Krumm, E Petrova, S Lechner, J Mergner, HH Boehm, A Prestipino, ...
Molecular & Cellular Proteomics 22 (9), 2023
2023
Chemoproteomics-based target deconvolution and selectivity profiling of Histone Deacetylase inhibitors
S Lechner
Technische Universität München, 2023
2023
Chemoproteomic target deconvolution of lipoic acid reveals Histone Deacetylases as the main targets
B Kuster, S Lechner, R Steimbach, L Wang, P Matthias, A Miller, ...
2022
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target (Apr, 10.1038/s41589-022-01015-5, 2022)
S Lechner, MIP Malgapo, C Graetz, RR Steimbach, A Baron, P Ruether, ...
NATURE CHEMICAL BIOLOGY 18 (8), 913-913, 2022
2022
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