Francisco León
Francisco León
Asistant Professor
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Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine
SE Hemby, S McIntosh, F Leon, SJ Cutler, CR McCurdy
Addiction biology 24 (5), 874-885, 2019
Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based kratom …
S Obeng, SH Kamble, ME Reeves, LF Restrepo, A Patel, M Behnke, ...
Journal of medicinal chemistry 63 (1), 433-439, 2019
Phytochemical Characterization of the Leaves of Mitragyna Speciosa Grown in USA
F León, E Habib, JE Adkins, EB Furr, CR McCurdy, SJ Cutler
Natural product communications 4 (7), 1934578X0900400705, 2009
Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)
SH Kamble, A Sharma, TI King, F León, CR McCurdy, BA Avery
Xenobiotica, 0
Lanostanoid Triterpenes from Laetiporus s ulph u reus and Apoptosis Induction on HL-60 Human Myeloid Leukemia Cells
F León, J Quintana, A Rivera, F Estévez, J Bermejo
Journal of natural products 67 (12), 2008-2011, 2004
Steroidal Saponins from the Bark of Dracaena draco and Their Cytotoxic Activities
AG González, JC Hernández, F León, JI Padrón, F Estévez, J Quintana, ...
Journal of natural products 66 (6), 793-798, 2003
New Lanostanoids from the Fungus Ganoderma c oncinna
AG González, F León, A Rivera, JI Padrón, J González-Plata, JC Zuluaga, ...
Journal of natural products 65 (3), 417-421, 2002
Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra‐performance liquid chromatography …
A Sharma, SH Kamble, F León, NJY Chear, TI King, EC Berthold, ...
Drug testing and analysis 11 (8), 1162-1171, 2019
Lanostanoid Triterpenes from Ganoderma l ucidum
AG González, F León, A Rivera, CM Muñoz, J Bermejo
Journal of natural products 62 (12), 1700-1701, 1999
Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users
D Singh, NJY Chear, S Narayanan, F Leon, A Sharma, CR McCurdy, ...
Journal of Ethnopharmacology 249, 112462, 2020
Perspective on the Therapeutics of Anti-Snake Venom
I Gómez-Betancur, V Gogineni, A Salazar-Ospina, F León
Molecules 24 (18), 3276, 2019
Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants
F Larit, KM Elokely, ND Chaurasiya, S Benyahia, MA Nael, F León, ...
Phytomedicine 40, 27-36, 2018
A flavonoid with cytotoxic activity and other constituents from Centaurea africana
R Seghiri, O Boumaza, R Mekkiou, S Benayache, P Mosset, J Quintana, ...
Phytochemistry Letters 2 (3), 114-118, 2009
Phenolic Compounds of Dragon's Blood from Dracaena d raco
AG González, F León, L Sánchez-Pinto, JI Padrón, J Bermejo
Journal of natural products 63 (9), 1297-1299, 2000
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for Mu-Opioid Receptor and Opioid-Like Behavioral Effects in Rats
Journal of Pharmacology and Experimental Therapeutics 376 (3), 410-427, 2021
Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco
JC Hernandez, F León, J Quintana, F Estévez, J Bermejo
Bioorganic & medicinal chemistry 12 (16), 4423-4429, 2004
Novel cytostatic lanostanoid triterpenes from Ganoderma australe
F Leon, M Valencia, A Rivera, I Nieto, J Quintana, F Estevez, J Bermejo
Helvetica chimica acta 86 (9), 3088-3095, 2003
Synthesis and antiproliferative activity of a new compound containing an α-methylene-γ-lactone group
AG González, MH Silva, JI Padrón, F León, E Reyes, M Álvarez-Mon, ...
Journal of medicinal chemistry 45 (12), 2358-2361, 2002
Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia
D Singh, S Narayanan, CP Müller, MT Swogger, NJY Chear, EB Dzulkapli, ...
Journal of ethnopharmacology 233, 34-40, 2019
Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens
J Gao, MM Radwan, F León, X Wang, MR Jacob, BL Tekwani, SI Khan, ...
Medicinal Chemistry Research 21, 3080-3086, 2012
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