Следене
Friedrich Reinhard
Friedrich Reinhard
VP Academic Partnerships, Evotec International GmbH
Потвърден имейл адрес: evotec.com - Начална страница
Заглавие
Позовавания
Позовавания
Година
Tracking cancer drugs in living cells by thermal profiling of the proteome
MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ...
Science 346 (6205), 2014
7792014
A novel ϵ-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
A Weidemann, S Eggert, FBM Reinhard, M Vogel, K Paliga, G Baier, ...
Biochemistry 41 (8), 2825-2835, 2002
4802002
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
H Franken, T Mathieson, D Childs, GMA Sweetman, T Werner, I Tögel, ...
Nature protocols 10 (10), 1567-1593, 2015
4132015
Thermal proteome profiling monitors ligand interactions with cellular membrane proteins
FBM Reinhard, D Eberhard, T Werner, H Franken, D Childs, C Doce, ...
Nature methods 12 (12), 1129-1131, 2015
2272015
Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
A Weidemann, K Paliga, U Durrwang, FBM Reinhard, O Schuckert, G Evin, ...
Journal of Biological Chemistry 274 (9), 5823-5829, 1999
2191999
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation
G Bergamini, K Bell, S Shimamura, T Werner, A Cansfield, K Müller, ...
Nature chemical biology 8 (6), 576-582, 2012
1392012
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
G Evin, RA Sharples, A Weidemann, FBM Reinhard, V Carbone, ...
Biochemistry 40 (28), 8359-8368, 2001
492001
Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells
HC Eberl, T Werner, FB Reinhard, S Lehmann, D Thomson, P Chen, ...
Scientific reports 9 (1), 14159, 2019
402019
Mixed Lithium Magnesium Aryl Oxides Derived from Cresol: Crystal Structures and Solution NMR Studies of an Unexpected, Magnesium-Rich Oxo Product with a Trigonal Bipyramidal …
KW Henderson, RE Mulvey, FBM Reinhard, W Clegg, L Horsburgh
Journal of the American Chemical Society 116 (23), 10777-10778, 1994
311994
Clinically relevant OATP2B1 inhibitors in marketed drug space
MS Unger, J Mudunuru, M Schwab, C Hopf, G Drewes, AT Nies, ...
Molecular pharmaceutics 17 (2), 488-498, 2019
142019
Screening pools of compounds against multiple endogenously expressed targets in a chemoproteomics binding assay
E Salzer, E Nixon, G Drewes, F Reinhard, G Bergamini, C Rau
Journal of Laboratory Automation 21 (1), 133-142, 2016
112016
Optimization of orally bioavailable PI3Kδ inhibitors and identification of Vps34 as a key selectivity target
ZA Henley, A Amour, N Barton, M Bantscheff, G Bergamini, SM Bertrand, ...
Journal of Medicinal Chemistry 63 (2), 638-655, 2019
102019
Direct automated MALDI mass spectrometry analysis of cellular transporter function: inhibition of OATP2B1 uptake by 294 drugs
MS Unger, L Schumacher, T Enzlein, D Weigt, MJ Zamek-Gliszczynski, ...
Analytical Chemistry 92 (17), 11851-11859, 2020
62020
Investigation of Janus kinase (JAK) inhibitors for lung delivery and the importance of aldehyde oxidase metabolism
CR Wellaway, IR Baldwin, P Bamborough, D Barker, MA Bartholomew, ...
Journal of Medicinal Chemistry 65 (1), 633-664, 2021
32021
Working with small molecules: Preparing and storing stock solutions and determination of kinetic solubility
A Wolf, S Shimamura, FBM Reinhard
Chemical Proteomics: Methods and Protocols, 265-271, 2012
22012
CELL BIOLOGY AND METABOLISM-Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
A Weidemann, K Paliga, U Durrwang, FBM Reinhard, O Schuckert, G Evin, ...
Journal of Biological Chemistry 274 (9), 5823-5829, 1999
11999
PHENYLSULFONAMIDE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE
BAUMANN-KARLHEINZ, GM JEAN, GRIEBENOW-NILS, ...
WO2004080952A1, 2004
2004
Struktur und Funktion der Preseniline sowie ihre Wechselwirkungen mit anderen für die Alzheimer-Krankheit relevanten Proteinen
F Reinhard
na, 2001
2001
Proteolytic processing of the APP gene family members APLP-1 and APLP-2
S Eggert, FBM Reinhard, K Paliga, J Stumm, S Scheuermann, ...
Neurobiology of Aging, 263, 2000
2000
Analysis of the role of charge residues in the transmembrane domains of presenilin-2
FBM Reinhard, S Eggert, S Kreger, PA Soba, A Weidemann
Neurobiology of Aging, 112, 2000
2000
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