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Wayne Fairbrother
Wayne Fairbrother
Verified email at gene.com
Title
Cited by
Cited by
Year
Protein NMR spectroscopy: principles and practice
J Cavanagh
Academic press, 1996
44241996
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ...
Nature medicine 19 (2), 202-208, 2013
30452013
IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
E Varfolomeev, JW Blankenship, SM Wayson, AV Fedorova, N Kayagaki, ...
Cell 131 (4), 669-681, 2007
14212007
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ...
Nature 471 (7336), 110-114, 2011
8582011
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
A Ashkenazi, WJ Fairbrother, JD Leverson, AJ Souers
Nature reviews drug discovery 16 (4), 273-284, 2017
8342017
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
E Varfolomeev, T Goncharov, AV Fedorova, JN Dynek, K Zobel, ...
Journal of Biological Chemistry 283 (36), 24295-24299, 2008
6672008
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
JD Leverson, DC Phillips, MJ Mitten, ER Boghaert, D Diaz, SK Tahir, ...
Science translational medicine 7 (279), 279ra40-279ra40, 2015
5362015
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
JD Leverson, H Zhang, J Chen, SK Tahir, DC Phillips, J Xue, P Nimmer, ...
Cell death & disease 6 (1), e1590-e1590, 2015
4852015
Structure-guided design of a selective BCL-XL inhibitor
G Lessene, PE Czabotar, BE Sleebs, K Zobel, KN Lowes, JM Adams, ...
Nature chemical biology 9 (6), 390-397, 2013
4222013
c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling
JN Dynek, T Goncharov, EC Dueber, AV Fedorova, A Izrael‐Tomasevic, ...
The EMBO journal 29 (24), 4198-4209, 2010
3962010
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3
X Sun, J Yin, MA Starovasnik, WJ Fairbrother, VM Dixit
Journal of Biological Chemistry 277 (11), 9505-9511, 2002
3872002
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
D Vucic, K Deshayes, H Ackerly, MT Pisabarro, S Kadkhodayan, ...
Journal of biological chemistry 277 (14), 12275-12279, 2002
3312002
ICEBERG: a novel inhibitor of interleukin-1β generation
EW Humke, SK Shriver, MA Starovasnik, WJ Fairbrother, VM Dixit
Cell 103 (1), 99-111, 2000
3252000
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity
ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ...
ACS medicinal chemistry letters 5 (10), 1088-1093, 2014
3072014
Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models
EA Punnoose, JD Leverson, F Peale, ER Boghaert, LD Belmont, N Tan, ...
Molecular cancer therapeutics 15 (5), 1132-1144, 2016
2942016
Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase
J Gitschier, B Moffat, D Reilly, WI Wood, WJ Fairbrother
Nature structural biology 5 (1), 47-54, 1998
2871998
Exploring protein–protein interactions with phage display
SS Sidhu, WJ Fairbrother, K Deshayes
Chembiochem 4 (1), 14-25, 2003
2852003
Structure of C3b in complex with CRIg gives insights into regulation of complement activation
C Wiesmann, KJ Katschke, JP Yin, KY Helmy, M Steffek, WJ Fairbrother, ...
Nature 444 (7116), 217-220, 2006
2832006
The inhibitor of apoptosis proteins as therapeutic targets in cancer
D Vucic, WJ Fairbrother
Clinical cancer research 13 (20), 5995-6000, 2007
2812007
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)
JA Flygare, M Beresini, N Budha, H Chan, IT Chan, S Cheeti, F Cohen, ...
Journal of medicinal chemistry 55 (9), 4101-4113, 2012
2662012
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