| Structure of a WW domain containing fragment of dystrophin in complex with β-dystroglycan X Huang, F Poy, R Zhang, A Joachimiak, M Sudol, MJ Eck Nature Structural & Molecular Biology 7 (8), 634-638, 2000 | 358 | 2000 |
| Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2–p53 inhibitor in clinical development D Sun, Z Li, Y Rew, M Gribble, MD Bartberger, HP Beck, J Canon, A Chen, ... Journal of medicinal chemistry 57 (4), 1454-1472, 2014 | 324 | 2014 |
| Crystal structure of human glycine receptor-[agr] 3 bound to antagonist strychnine X Huang, H Chen, K Michelsen, S Schneider, PL Shaffer Nature 526 (7572), 277-280, 2015 | 250 | 2015 |
| Structure-based design of novel inhibitors of the MDM2–p53 interaction Y Rew, D Sun, F Gonzalez-Lopez De Turiso, MD Bartberger, HP Beck, ... Journal of medicinal chemistry 55 (11), 4936-4954, 2012 | 202 | 2012 |
| Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2− tumor protein 53 protein− protein interaction JG Allen, MP Bourbeau, GE Wohlhieter, MD Bartberger, K Michelsen, ... Journal of medicinal chemistry 52 (22), 7044-7053, 2009 | 188 | 2009 |
| Crystal structure of an inactive Akt2 kinase domain X Huang, M Begley, KA Morgenstern, Y Gu, P Rose, H Zhao, X Zhu Structure 11 (1), 21-30, 2003 | 161 | 2003 |
| Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations P Retailleau, X Huang, Y Yin, M Hu, V Weinreb, P Vachette, C Vonrhein, ... Journal of molecular biology 325 (1), 39-63, 2003 | 105 | 2003 |
| Selective and potent morpholinone inhibitors of the MDM2–p53 protein–protein interaction AZ Gonzalez, J Eksterowicz, MD Bartberger, HP Beck, J Canon, A Chen, ... Journal of medicinal chemistry 57 (6), 2472-2488, 2014 | 99 | 2014 |
| Rational design and binding mode duality of MDM2–p53 inhibitors F Gonzalez-Lopez de Turiso, D Sun, Y Rew, MD Bartberger, HP Beck, ... Journal of medicinal chemistry 56 (10), 4053-4070, 2013 | 94 | 2013 |
| Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors H Bregman, N Chakka, A Guzman-Perez, H Gunaydin, Y Gu, X Huang, ... Journal of medicinal chemistry 56 (11), 4320-4342, 2013 | 88 | 2013 |
| Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme LA Witucki, X Huang, K Shah, Y Liu, S Kyin, MJ Eck, KM Shokat Chemistry & biology 9 (1), 25-33, 2002 | 88 | 2002 |
| Ordering of the N-terminus of human MDM2 by small molecule inhibitors K Michelsen, JB Jordan, J Lewis, AM Long, E Yang, Y Rew, J Zhou, ... Journal of the American Chemical Society 134 (41), 17059-17067, 2012 | 86 | 2012 |
| Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido [5′, 4′: 5, 6] pyrimido [1, 2-a] benzimidazol-5 (6 H)-ones as Potent and Orally Active Inhibitors of Lymphocyte … MW Martin, J Newcomb, JJ Nunes, C Boucher, L Chai, LF Epstein, ... Journal of medicinal chemistry 51 (6), 1637-1648, 2008 | 79 | 2008 |
| Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity EF DiMauro, J Newcomb, JJ Nunes, JE Bemis, C Boucher, JL Buchanan, ... Journal of medicinal chemistry 49 (19), 5671-5686, 2006 | 79 | 2006 |
| Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction Y Rew, D Sun, X Yan, HP Beck, J Canon, A Chen, J Duquette, ... Journal of medicinal chemistry 57 (24), 10499-10511, 2014 | 75 | 2014 |
| Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres AZ Gonzalez, Z Li, HP Beck, J Canon, A Chen, D Chow, J Duquette, ... Journal of medicinal chemistry 57 (7), 2963-2988, 2014 | 73 | 2014 |
| Novel binding mode of a potent and selective tankyrase inhibitor H Gunaydin, Y Gu, X Huang PLoS One 7 (3), e33740, 2012 | 72 | 2012 |
| Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity MW Martin, J Newcomb, JJ Nunes, DC McGowan, DM Armistead, ... Journal of medicinal chemistry 49 (16), 4981-4991, 2006 | 68 | 2006 |
| Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase VJ Cee, AC Cheng, K Romero, S Bellon, C Mohr, DA Whittington, A Bak, ... Bioorganic & medicinal chemistry letters 19 (2), 424-427, 2009 | 63 | 2009 |
| The reaction of Cs (82P) and Cs (92P) with hydrogen molecules X Huang, J Zhao, G Xing, X Wang, R Bersohn The Journal of chemical physics 104 (4), 1338-1343, 1996 | 61 | 1996 |
