Discovery of multiple hidden allosteric sites by combining Markov state models and experiments GR Bowman, ER Bolin, KM Hart, BC Maguire, S Marqusee Proceedings of the National Academy of Sciences 112 (9), 2734-2739, 2015 | 215 | 2015 |
Modelling proteins' hidden conformations to predict antibiotic resistance KM Hart, CMW Ho, S Dutta, ML Gross, GR Bowman Nature Communications 7, 12965, 2016 | 134 | 2016 |
Cleavable hydrophilic linker for one-bead-one-compound sequencing of oligomer libraries by tandem mass spectrometry MG Paulick, KM Hart, KM Brinner, M Tjandra, DH Charych, ... Journal of combinatorial chemistry 8 (3), 417-426, 2006 | 113 | 2006 |
Thermodynamic system drift in protein evolution KM Hart, MJ Harms, BH Schmidt, C Elya, JW Thornton, S Marqusee PLoS biology 12 (11), e1001994, 2014 | 101 | 2014 |
Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models MI Zimmerman, KM Hart, CA Sibbald, TE Frederick, JR Jimah, ... ACS central science 3 (12), 1311-1321, 2017 | 75 | 2017 |
Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators KM Hart, KE Moeder, CMW Ho, MI Zimmerman, TE Frederick, ... PloS one 12 (6), e0178678, 2017 | 65 | 2017 |
Cooperative changes in solvent exposure identify cryptic pockets, switches, and allosteric coupling JR Porter, KE Moeder, CA Sibbald, MI Zimmerman, KM Hart, ... Biophysical journal 116 (5), 818-830, 2019 | 61 | 2019 |
Evolutionary trend toward kinetic stability in the folding trajectory of RNases H SA Lim, KM Hart, MJ Harms, S Marqusee Proceedings of the National Academy of Sciences 113 (46), 13045-13050, 2016 | 42 | 2016 |
BioBuilder: Synthetic biology in the lab N Kuldell, R Bernstein, K Ingram, KM Hart O'Reilly, 2015 | 40* | 2015 |
Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance KM Hart, M Reck, GR Bowman, TA Wencewicz MedChemComm 7 (1), 118-127, 2016 | 15 | 2016 |
BioBuilder: Synthetic biology in the lab R Bernstein, K Ingram, KM Hart " O'Reilly Media, Inc.", 2015 | 6 | 2015 |
Natural and Synthetic Suppressor Mutations Defy Stability–Activity Tradeoffs S Lee, CN Okoye, D Biesbrock, EC Harris, KF Miyasaki, RG Rilinger, ... Biochemistry 61 (5), 398-407, 2022 | 3 | 2022 |
Differential effects of disulfide bond formation in TEM‐1 versus CTX‐M‐9 β‐lactamase M Villanueva, LE Vostal, DN Cohen, D Biesbrock, EP Kuwaye, SG Driver, ... Protein Science 33 (1), e4816, 2024 | 2 | 2024 |