Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ... Nature chemistry 12 (5), 445-451, 2020 | 249 | 2020 |
Kinetic diversity of amyloid oligomers AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, ... Proceedings of the National Academy of Sciences 117 (22), 12087-12094, 2020 | 131 | 2020 |
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, ... Scientific Reports 5 (1), 16696, 2015 | 114 | 2015 |
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, ... Analytical chemistry 87 (17), 8818-8826, 2015 | 96 | 2015 |
Identification of on-and off-pathway oligomers in amyloid fibril formation AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, ... Chemical science 11 (24), 6236-6247, 2020 | 76 | 2020 |
Oligomer diversity during the aggregation of the repeat region of tau M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, ... ACS chemical neuroscience 9 (12), 3060-3071, 2018 | 63 | 2018 |
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, ... Scientific Reports 6 (1), 24656, 2016 | 62* | 2016 |
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, ... Scientific reports 6 (1), 28658, 2016 | 60 | 2016 |
Quantifying co-oligomer formation by α-synuclein M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ... ACS nano 12 (11), 10855-10866, 2018 | 53 | 2018 |
Direct observation of oligomerization by single molecule fluorescence reveals a multistep aggregation mechanism for the yeast prion protein Ure2 J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, ... Journal of the American Chemical Society 140 (7), 2493-2503, 2018 | 50 | 2018 |
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, ... Nature Structural & Molecular Biology 27 (10), 886-891, 2020 | 47 | 2020 |
Fluctuations in the kinetics of linear protein self-assembly TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles Physical review letters 116 (25), 258103, 2016 | 40 | 2016 |
On the mechanism of self-assembly by a hydrogel-forming peptide GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, ... Biomacromolecules 21 (12), 4781-4794, 2020 | 34 | 2020 |
Fabrication and characterization of reconstituted silk microgels for the storage and release of small molecules X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, ... Macromolecular rapid communications 40 (8), 1800898, 2019 | 33 | 2019 |
The catalytic nature of protein aggregation AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles The Journal of Chemical Physics 152 (4), 2020 | 32 | 2020 |
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species JC Sang, JE Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, ... Chemical science 10 (17), 4588-4597, 2019 | 29 | 2019 |
Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation GA Braun, AJ Dear, K Sanagavarapu, H Zetterberg, S Linse Chemical Science 13 (8), 2423-2439, 2022 | 23 | 2022 |
Stochastic calculus of protein filament formation under spatial confinement TCT Michaels, AJ Dear, TPJ Knowles New journal of physics 20 (5), 055007, 2018 | 22 | 2018 |
In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers E Zurlo, P Kumar, G Meisl, AJ Dear, D Mondal, MMAE Claessens, ... PLoS One 16 (1), e0245548, 2021 | 19 | 2021 |
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils J Yang, AJ Dear, QQ Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, ... Nanoscale 12 (36), 18663-18672, 2020 | 19 | 2020 |