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Samuel F. Bakhoum, M.D.,Ph.D.
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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
G Genovese, AK Kähler, RE Handsaker, J Lindberg, SA Rose, ...
New England Journal of Medicine 371 (26), 2477-2487, 2014
33872014
Chromosomal instability drives metastasis through a cytosolic DNA response
SF Bakhoum, B Ngo, AM Laughney, JA Cavallo, CJ Murphy, P Ly, P Shah, ...
Nature 553 (7689), 467-472, 2018
12512018
Mechanisms of chromosomal instability
SL Thompson, SF Bakhoum, DA Compton
Current Biology 20 (6), R285-R295, 2010
7162010
The cytosolic DNA-sensing cGAS–STING pathway in cancer
J Kwon, SF Bakhoum
Cancer discovery 10 (1), 26-39, 2020
6882020
The multifaceted role of chromosomal instability in cancer and its microenvironment
SF Bakhoum, LC Cantley
Cell 174 (6), 1347-1360, 2018
5672018
Genome stability is ensured by temporal control of kinetochore–microtubule dynamics
SF Bakhoum, SL Thompson, AL Manning, DA Compton
Nature cell biology 11 (1), 27-35, 2009
5122009
A molecular single-cell lung atlas of lethal COVID-19
JC Melms, J Biermann, H Huang, Y Wang, A Nair, S Tagore, I Katsyv, ...
Nature 595 (7865), 114-119, 2021
5092021
Deviant kinetochore microtubule dynamics underlie chromosomal instability
SF Bakhoum, G Genovese, DA Compton
Current Biology 19 (22), 1937-1942, 2009
3882009
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations
PR Loh, G Genovese, RE Handsaker, HK Finucane, YA Reshef, ...
Nature 559 (7714), 350-355, 2018
3312018
Regenerative lineages and immune-mediated pruning in lung cancer metastasis
AM Laughney, J Hu, NR Campbell, SF Bakhoum, M Setty, VP Lavallée, ...
Nature medicine 26 (2), 259-269, 2020
3242020
Chromosomal instability and cancer: a complex relationship with therapeutic potential
SF Bakhoum, DA Compton
The Journal of clinical investigation 122 (4), 1138-1143, 2012
3182012
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
B Nguyen, C Fong, A Luthra, SA Smith, RG DiNatale, S Nandakumar, ...
Cell 185 (3), 563-575. e11, 2022
3172022
Pervasive chromosomal instability and karyotype order in tumour evolution
TBK Watkins, EL Lim, M Petkovic, S Elizalde, NJ Birkbak, GA Wilson, ...
Nature 587 (7832), 126-132, 2020
2932020
The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells
AL Manning, NJ Ganem, SF Bakhoum, M Wagenbach, L Wordeman, ...
Molecular biology of the cell 18 (8), 2970-2979, 2007
2612007
A predictive model of complications after spine surgery: the National Surgical Quality Improvement Program (NSQIP) 2005–2010
K Bekelis, A Desai, SF Bakhoum, S Missios
The Spine Journal 14 (7), 1247-1255, 2014
1892014
Metastasis and immune evasion from extracellular cGAMP hydrolysis
J Li, MA Duran, N Dhanota, WK Chatila, SE Bettigole, J Kwon, RK Sriram, ...
Cancer discovery 11 (5), 1212-1227, 2021
1822021
Limited environmental serine and glycine confer brain metastasis sensitivity to PHGDH inhibition
B Ngo, E Kim, V Osorio-Vasquez, S Doll, S Bustraan, RJ Liang, A Luengo, ...
Cancer discovery 10 (9), 1352-1373, 2020
1772020
The mitotic origin of chromosomal instability
SF Bakhoum, WT Silkworth, IK Nardi, JM Nicholson, DA Compton, ...
Current Biology 24 (4), R148-R149, 2014
1712014
Chromosomal instability as a driver of tumor heterogeneity and evolution
SF Bakhoum, DA Landau
Cold Spring Harbor perspectives in medicine 7 (6), a029611, 2017
1672017
DNA-damage response during mitosis induces whole-chromosome missegregation
SF Bakhoum, L Kabeche, JP Murnane, BI Zaki, DA Compton
Cancer discovery 4 (11), 1281-1289, 2014
1652014
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Articles 1–20