Следене
Michael Harbut
Michael Harbut
Janssen Research & Development
Потвърден имейл адрес: its.jnj.com
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Позовавания
Позовавания
Година
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
MB Harbut, C Vilchèze, X Luo, ME Hensler, H Guo, B Yang, AK Chatterjee, ...
Proceedings of the National Academy of Sciences 112 (14), 4453-4458, 2015
3122015
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells
R Chandramohanadas, PH Davis, DP Beiting, MB Harbut, C Darling, ...
science 324 (5928), 794-797, 2009
2002009
Role for DNA polymerase κ in the processing of N2-N2-guanine interstrand cross-links
IG Minko, MB Harbut, ID Kozekov, A Kozekova, PM Jakobs, SB Olson, ...
Journal of biological chemistry 283 (25), 17075-17082, 2008
1592008
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases
MB Harbut, G Velmourougane, S Dalal, G Reiss, JC Whisstock, O Onder, ...
Proceedings of the National Academy of Sciences 108 (34), E526-E534, 2011
1472011
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
MB Harbut, BA Patel, BKS Yeung, CW McNamara, AT Bright, J Ballard, ...
Proceedings of the National Academy of Sciences 109 (52), 21486-21491, 2012
1082012
Synthesis of new (−)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase
G Velmourougane, MB Harbut, S Dalal, S McGowan, CA Oellig, ...
Journal of medicinal chemistry 54 (6), 1655-1666, 2011
832011
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB
JP Mallari, AA Shelat, T Obrien, CR Caffrey, A Kosinski, M Connelly, ...
Journal of Medicinal Chemistry 51 (3), 545-552, 2008
702008
Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV
A Kumari, IG Minko, MB Harbut, SE Finkel, MF Goodman, RS Lloyd
Journal of Biological Chemistry 283 (41), 27433-27437, 2008
612008
Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase exhibit antimycobacterial activity
MB Harbut, B Yang, R Liu, T Yano, C Vilchèze, B Cheng, J Lockner, ...
Angewandte Chemie 130 (13), 3536-3540, 2018
572018
Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
F Mietton, EF Ferri, M Champleboux, N Zala, D Maubon, Y Zhou, ...
Nature Communications 8 (15482), 2017
452017
Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes
R Liu, X Lyu, SM Batt, MH Hsu, MB Harbut, C Vilchèze, B Cheng, K Ajayi, ...
Angewandte Chemie International Edition 56 (42), 13011-13015, 2017
432017
Development of bestatin-based activity-based probes for metallo-aminopeptidases
MB Harbut, G Velmourougane, G Reiss, R Chandramohanadas, ...
Bioorganic & medicinal chemistry letters 18 (22), 5932-5936, 2008
402008
Replication Bypass of N2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerases η and ι
AR Klug, MB Harbut, RS Lloyd, IG Minko
Chemical research in toxicology 25 (3), 755-762, 2012
372012
Identification of small-molecule protein–protein interaction inhibitors for NKG2D
AA Thompson, MB Harbut, PP Kung, NK Karpowich, JD Branson, ...
Proceedings of the National Academy of Sciences 120 (18), e2216342120, 2023
32023
Modulation of the turnover of formamidopyrimidine DNA glycosylase
MB Harbut, M Meador, ML Dodson, RS Lloyd
Biochemistry 45 (23), 7341-7346, 2006
22006
Diastereoselective Synthesis of (–)-Bestatin, Epibestatin, Phebestin and (3S, 4R)-4-Amino-3-hydroxy-5-phenylpentanoic Acid from an Aldehyde Derived from d-Phenylalanine
VK Jain
SynOpen 3 (04), 114-123, 2019
12019
Chemical Genetic Approaches for Elucidating Protease Function and Drug-Target Potential in Plasmodium Falciparum
MB Harbut
University of Pennsylvania, 2012
2012
Bypass of N-2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerase Eta
IG Minko, AR Klug, MB Harbut, RS Lloyd
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 51 (7), 713-713, 2010
2010
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Статии 1–18