Tanja Mittag
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Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization
A Molliex, J Temirov, J Lee, M Coughlin, AP Kanagaraj, HJ Kim, T Mittag, ...
Cell 163 (1), 123-133, 2015
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
S Alberti, A Gladfelter, T Mittag
Cell 176 (3), 419-434, 2019
Protein phase separation: a new phase in cell biology
S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ...
Trends in cell biology 28 (6), 420-435, 2018
G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
P Yang, C Mathieu, RM Kolaitis, P Zhang, J Messing, U Yurtsever, Z Yang, ...
Cell 181 (2), 325-345. e28, 2020
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
EW Martin, AS Holehouse, I Peran, M Farag, JJ Incicco, A Bremer, ...
Science 367 (6478), 694-699, 2020
TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics
IR Mackenzie, AM Nicholson, M Sarkar, J Messing, MD Purice, C Pottier, ...
Neuron 95 (4), 808-816. e9, 2017
Atomic-level characterization of disordered protein ensembles
T Mittag, JD Forman-Kay
Current opinion in structural biology 17 (1), 3-14, 2007
Protein dynamics and conformational disorder in molecular recognition
T Mittag, LE Kay, JD Forman‐Kay
Journal of Molecular Recognition: An Interdisciplinary Journal 23 (2), 105-116, 2010
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
T Mittag, S Orlicky, WY Choy, X Tang, H Lin, F Sicheri, LE Kay, M Tyers, ...
Proceedings of the National Academy of Sciences 105 (46), 17772-17777, 2008
A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing
A Wang, AE Conicella, HB Schmidt, EW Martin, SN Rhoads, AN Reeb, ...
The EMBO journal 37 (5), e97452, 2018
Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions
EW Martin, T Mittag
Biochemistry 57 (17), 2478-2487, 2018
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
JJ Bouchard, JH Otero, DC Scott, E Szulc, EW Martin, N Sabri, D Granata, ...
Molecular Cell 72 (1), 19-36, 2018
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase
T Mittag, J Marsh, A Grishaev, S Orlicky, H Lin, F Sicheri, M Tyers, ...
Structure 18 (4), 494-506, 2010
A conceptual framework for understanding phase separation and addressing open questions and challenges
T Mittag, RV Pappu
Molecular cell 82 (12), 2201-2214, 2022
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
A Bremer, M Farag, WM Borcherds, I Peran, EW Martin, RV Pappu, ...
Nature Chemistry 14 (2), 196-207, 2022
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity
M Borg, T Mittag, T Pawson, M Tyers, JD Forman-Kay, HS Chan
Proceedings of the National Academy of Sciences 104 (23), 9650-9655, 2007
From sequence and forces to structure, function, and evolution of intrinsically disordered proteins
JD Forman-Kay, T Mittag
Structure 21 (9), 1492-1499, 2013
Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation
EW Martin, AS Holehouse, CR Grace, A Hughes, RV Pappu, T Mittag
Journal of the American Chemical Society 138 (47), 15323-15335, 2016
Conformational switches modulate protein interactions in peptide antibiotic synthetases
A Koglin, MR Mofid, F Löhr, B Schäfer, VV Rogov, MM Blum, T Mittag, ...
Science 312 (5771), 273-276, 2006
Multiple modes of protein–protein interactions promote RNP granule assembly
T Mittag, R Parker
Journal of molecular biology 430 (23), 4636-4649, 2018
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